Cancer CXC chemokine networks and tumour angiogenesis

被引：380

作者：

Strieter, RM

Burdick, MD

Mestas, J

Gomperts, B

Keane, MP

Belperio, JA

机构：

[1] Univ Calif Los Angeles, David Geffen Sch Med, Div Pulm & Crit Care Med, Dept Med, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, David Geffen Sch Med, Div Pulm & Crit Care Med, Dept Pathol, Los Angeles, CA 90095 USA

[3] Univ Calif Los Angeles, David Geffen Sch Med, Div Pulm & Crit Care Med, Dept Pediat, Los Angeles, CA 90095 USA

来源：

EUROPEAN JOURNAL OF CANCER | 2006年 / 42卷 / 06期

关键词：

CXC chemokines; angiogenesis; angiostasis; tumourigenesis; cancer;

D O I：

10.1016/j.ejca.2006.01.006

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Chemokines have pleiotropic effects in regulating immunity, angiogenesis, stem cell trafficking, and mediating organ-specific metastases of cancer. In the context of angiogenesis, the CXC chemokine family is a unique group of cytokines known for their ability to behave in a disparate manner in the regulation of angiogenesis. The glutamic acid-leucine-arginine (ELR+) CXC chemokines are potent promoters of angiogenesis, and mediate their angiogenic activity via signal-coupling of CXCR2 on endothelium. By contrast, members of the CXC chemokine family, such as platelet factor-4 (PF4; CXCL4) and interferon-inducible CXC chemokines are potent inhibitors of angiogenesis, and use CXCR3 on endothelium to mediate their angiostatic activity. This review will discuss the biology of CXC chemokines in the context of angiogenesis related to cancer. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：768 / 778

页数：11

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