Numerous Genes in Loci Associated With Body Fat Distribution Are Linked to Adipose Function

被引：38

作者：

Dahlman, Ingrid ^{[1
,2
]}

Ryden, Mikael ^{[1
,2
]}

Brodin, David ^{[3
]}

Grallert, Harald ^{[4
,5
,6
]}

Strawbridge, Rona J. ^{[2
,7
]}

Amer, Peter ^{[1
,2
]}

机构：

[1] Dept Med, Huddinge, Sweden

[2] Karolinska Inst, Stockholm, Sweden

[3] Karolinska Inst, Dept Biosci & Nutr, Stockholm, Sweden

[4] German Ctr Diabet Res DZD, Neuherberg, Germany

[5] German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Res Unit Mol Epidemiol, Neuherberg, Germany

[6] German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Inst Epidemiol 2, Neuherberg, Germany

[7] Dept Med, Atherosclerosis Res Unit, Cardiovasc Genet & Genom Grp, Solna, Sweden

来源：

DIABETES | 2016年 / 65卷 / 02期

基金：

瑞典研究理事会;

关键词：

INSULIN;

D O I：

10.2337/db15-0828

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Central fat accumulation is a strong risk factor for type 2 diabetes. Genome-wide association studies have identified numerous loci associated with body fat distribution. The objectives of the current study are to examine whether genes in genetic loci linked to fat distribution can be linked to fat cell size and number (morphology) and/or adipose tissue function. We show, in a cohort of 114 women, that almost half of the 96 genes in these loci are indeed associated with abdominal subcutaneous adipose tissue parameters. Thus, adipose mRNA expression of the genes is strongly related to adipose morphology, catecholamine-induced lipid mobilization (lipolysis), or insulin-stimulated lipid synthesis in adipocytes (lipogenesis). In conclusion, the genetic influence on body fat distribution could be mediated via several specific alterations in adipose tissue morphology and function, which in turn may influence the development of type 2 diabetes.

引用

页码：433 / 437

页数：5

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