In vitro activities of tritrpticin alone and in combination with other antimicrobial agents against Pseudomonas aeruginosa

被引：19

作者：

Cirioni, Oscar ^{[1
]}

Giacometti, Andrea ^{[1
]}

Silvestri, Carmela ^{[1
]}

Della Vittoria, Agnese ^{[1
]}

Licci, Alberto ^{[1
]}

Riva, Alessandra ^{[1
]}

Scalise, Giorgio ^{[1
]}

机构：

[1] Univ Politecn Marche, Osped Riuniti Ancona, Inst Infect Dis & Publ Hlth, Ancona, Italy

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2006年 / 50卷 / 11期

关键词：

PEPTIDE TRITRPTICIN; ANTIBIOTICS; RESISTANCE; MECHANISMS; EMERGENCE;

D O I：

10.1128/AAC.00652-06

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The in vitro activity of the cathelicidin tritrpticin was investigated against multidrug-resistant Pseudomonas aeruginosa. The isolates were susceptible to the peptide at concentrations of 0.50 to 8 mg/liter. Tritrpticin completely inhibits lipopolysaccharide procoagulant activity at a 10 p,M concentration. Fractionary inhibitory concentration indexes (0.385, 0.312, and 0.458) demonstrated synergy between the peptide and beta-lactams.

引用

页码：3923 / 3925

页数：3

共 23 条

[1] ANTIMICROBIAL PEPTIDES - A FAMILY OF WOUND HEALERS [J].

CANNON, M .

NATURE, 1987, 328 (6130) :478-478

[2] Emergence of antibiotic-resistant Pseudomonas aeruginosa:: Comparison of risks associated with different antipseudomonal agents [J].

Carmeli, Y ;

Troillet, N ;

Eliopoulos, GM ;

Samore, MH .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1999, 43 (06) :1379-1382

[3] Effectiveness of combination antimicrobial therapy for Pseudomonas aeruginosa bacteremia [J].

Chamot, E ;

El Amari, EB ;

Rohner, P ;

Van Delden, C .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2003, 47 (09) :2756-2764

[4]

COHEN J, 1985, LANCET, V2, P1069

[5] BETA-LACTAM ANTIBIOTICS POTENTIATE MAGAININ-2 ANTIMICROBIAL ACTIVITY INVITRO AND INVIVO [J].

DARVEAU, RP ;

CUNNINGHAM, MD ;

SEACHORD, CL ;

CASSIANOCLOUGH, L ;

COSAND, WL ;

BLAKE, J ;

WATKINS, CS .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1991, 35 (06) :1153-1159

[6] Covalent polymyxin B conjugate with human immunoglobulin G as an antiendotoxin reagent [J].

Drabick, JJ ;

Bhattacharjee, AK ;

Hoover, DL ;

Siber, GE ;

Morales, VE ;

Young, LD ;

Brown, SL ;

Cross, AS .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1998, 42 (03) :583-588

[7]

Eliopolous GM., 1996, Antibiotics in laboratory medicine, P330

[8] Cathelicidin peptide sheep myeloid antimicrobial peptide-29 prevents endotoxin-induced mortality in rat models of septic shock [J].

Giacometti, A ;

Cirioni, O ;

Ghiselli, R ;

Mocchegiani, F ;

D'Amato, G ;

Circo, R ;

Orlando, F ;

Skerlavaj, B ;

Silvestri, C ;

Saba, V ;

Zanetti, M ;

Scalise, G .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2004, 169 (02) :187-194

[9] Antiendotoxin activity of cationic peptide antimicrobial agents [J].

Gough, M ;

Hancock, REW ;

Kelly, NM .

INFECTION AND IMMUNITY, 1996, 64 (12) :4922-4927

[10] The role of antimicrobial peptides in animal defenses [J].

Hancock, REW ;

Scott, MG .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (16) :8856-8861

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