A Boron-10 nitride nanosheet for combinational boron neutron capture therapy and chemotherapy of tumor

被引:42
作者
Li, Liping [1 ]
Dai, Kun [2 ]
Li, Jiyuan [3 ]
Shi, Yaxin [3 ]
Zhang, Zizhu [4 ]
Liu, Tong [4 ]
Xie, Jun [1 ]
Zhang, Ruiping [5 ]
Liu, Zhibo [2 ,3 ]
机构
[1] Shanxi Med Univ, Sch Basic Med Sci, Taiyuan 030001, Peoples R China
[2] Peking Univ, Tsinghua Univ, Ctr Life Sci, Beijing 100871, Peoples R China
[3] Peking Univ, Coll Chem & Mol Engn, Beijing Natl Lab Mol Sci, Beijing 100871, Peoples R China
[4] Beijing Capture Tech Co Ltd, Beijing 102413, Peoples R China
[5] Shanxi Med Univ, Shanxi Acad Med Sci, Shanxi Bethune Hosp, Radiol Dept,Hosp 3, Taiyuan 030032, Peoples R China
基金
中国博士后科学基金; 山西省青年科学基金;
关键词
Boron nitride nanosheets; Neutron-facilitated drug release; Boron neutron capture therapy; Radiochemotherapy; Triple-negative breast cancer; DRUG-DELIVERY; CANCER; GRAPHENE; NANOPARTICLES; RADIOTHERAPY; CELLS;
D O I
10.1016/j.biomaterials.2020.120587
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
Combination cancer therapy (e.g., radiochemotherapy) is widely used to enhance the therapeutic effects and prevent the recurrence of cancer. However, the side effects of monotherapy are also amplified when treating cancer with combination therapy. A locally activated drug delivery strategy that can release the payload in a tumor-selective manner is greatly needed to overcome the side effects of combination therapy. Here, we explore the potential of combining boron neutron capture therapy and chemotherapy as a new type of radio chemotherapy. Two-dimensional (2D) boron-10-rich nanosheets (BNNSs) were fabricated as a dual-functional delivery system: targeted boron-10 delivery systems for boron neutron capture therapy (BNCT) and drug delivery vehicles to load doxorubicin for chemotherapy. Irradiated by low-energy thermal neutron, BNNSs can produce high linear energy transfer (LET) particles to kill tumor cells, and the loaded doxorubicin can be released in situ at the same time. This neutron-triggered radiochemotherapy shows noteworthy efficacy in suppressing tumor growth in triple-negative breast cancer. To the best of our knowledge, this is the first report to combine BNCT with chemotherapy as a new type of radiochemotherapy. We hope this study could inspire additional BNCT-induced combination cancer therapies and provide insight for the further clinical translation of BNCT.yy
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页数:8
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