A new micro/nanoencapsulated porphyrin formulation for PDT treatment

被引：37

作者：

Deda, Daiana K. ^{[1
]}

Uchoa, Adjaci F. ^{[1
]}

Carita, Eduardo ^{[1
]}

Baptista, Mauricio S. ^{[1
]}

Toma, Henrique E. ^{[1
]}

Araki, Koiti ^{[1
]}

机构：

[1] Univ Sao Paulo, Inst Chem, BR-05508000 Sao Paulo, Brazil

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2009年 / 376卷 / 1-2期

基金：

巴西圣保罗研究基金会;

关键词：

Cationic porphyrin; Polymeric encapsulation; PDT; HeLa cells; CATIONIC TETRARUTHENATED PORPHYRIN; N-CONFUSED PORPHYRIN; OF-THE-ART; PHOTODYNAMIC THERAPY; PHOTOPHYSICAL PROPERTIES; PROCESSING PARAMETERS; NANOPARTICLES; DELIVERY; PHOTOSENSITIZERS; COACERVATION;

D O I：

10.1016/j.ijpharm.2009.04.024

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The highly hydrophobic 5,10,15-triphenyl-20-(3-N-methylpyridinium-yl)porphyrin(3MMe)cationic species was synthesized, characterized and encapsulated in marine atelocollagen/xanthane gum microcapsules by the coacervation method. Further reduction in the capsule size, from several microns down to about 300-400 nm, was carried out successfully by ultrasonic processing in the presence of up to 1.6% Tween 20 surfactant, without affecting the distribution of 3MMe in the oily core. The resulting creamlike product exhibited enhanced photodynamic activity but negligible cytotoxicity towards HeLa cells. The polymeric micro/nanocapsule formulation was found to be about 4 times more phototoxic than the respective phosphatidylcholine lipidic emulsion, demonstrating high potentiality for photodynamic therapy applications. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：76 / 83

页数：8

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