Novel approaches to whole sporozoite vaccination against malaria

被引：40

作者：

Bijker, Else M. ^{[1
]}

Borrmann, Steffen ^{[2
,3
,4
]}

Kappe, Stefan H. ^{[5
,6
]}

Mordmueller, Benjamin ^{[2
,3
,7
]}

Sack, Brandon K. ^{[5
]}

Khan, Shahid M. ^{[8
]}

机构：

[1] Radboud Univ Nijmegen, Med Ctr, Dept Med Microbiol, NL-6500 HB Nijmegen, Netherlands

[2] Univ Tubingen, Inst Trop Med, Tubingen, Germany

[3] Univ Tubingen, German Ctr Infect Res, Tubingen, Germany

[4] Kenya Govt Med Res Ctr, Wellcome Trust Res Programme, Kilifi, Kenya

[5] Seattle Biomed Res Inst, Seattle, WA 98109 USA

[6] Univ Washington, Dept Global Hlth, Seattle, WA 98195 USA

[7] Alberts Schweitzer Hosp, Ctr Rech Medicates Lambarene, Lambarene, Gabon

[8] Leiden Univ, Med Ctr, Dept Parasitol, NL-2300 RC Leiden, Netherlands

来源：

VACCINE | 2015年 / 33卷 / 52期

关键词：

Malaria; Plasmodium; Vaccine; Immunization; Sporozoite; Chemoprophylaxis; Chloroquine; Genetic attenuation; Liver stage; Pre-erythrocytic stages; CD8+ T-CELLS; PLASMODIUM-BERGHEI; LIVER-STAGE; PREERYTHROCYTIC STAGES; PROTECTIVE IMMUNITY; ATTENUATED SPOROZOITES; STERILE PROTECTION; ACQUIRED-IMMUNITY; HUMAN VOLUNTEERS; B-CELL;

D O I：

10.1016/j.vaccine.2015.09.095

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The parasitic disease malaria threatens more than 3 billion people worldwide, resulting in more than 200 million clinical cases and almost 600,000 deaths annually. Vaccines remain crucial for prevention and ultimately eradication of infectious diseases and, for malaria, whole sporozoite based immunization has been shown to be the most effective in experimental settings. In addition to immunization with radiation-attenuated sporozoites, chemoprophylaxis and sporozoites (CPS) is a highly efficient strategy to induce sterile protection in humans. Genetically attenuated parasites (GAP) have demonstrated significant protection in rodent studies, and are now being advanced into clinical testing. This review describes the existing pre-clinical and clinical data on CPS and GAP, discusses recent developments and examines how to transform these immunization approaches into vaccine candidates for clinical development. (C) 2015 Elsevier Ltd.

引用

页码：7462 / 7468

页数：7

共 90 条

[1] A Research Agenda for Malaria Eradication: Vaccines [J].

Alonso, Pedro L. ;

Ballou, Ripley ;

Brown, Graham ;

Chitnis, Chetan ;

Loucq, Christian ;

Moorthy, Vasee ;

Saul, Allan ;

Wirth, Dyann .

PLOS MEDICINE, 2011, 8 (01)

[2] Targeted deletion of SAP1 abolishes the expression of infectivity factors necessary for successful malaria parasite liver infection [J].

Aly, Ahmed S. I. ;

Mikolajczak, Sebastian A. ;

Rivera, Hilda Silva ;

Camargo, Nelly ;

Jacobs-Lorena, Vanessa ;

Labaied, Mehdi ;

Coppens, Isabelle ;

Kappe, Stefan H. I. .

MOLECULAR MICROBIOLOGY, 2008, 69 (01) :152-163

[3] SAP1 is a critical post-transcriptional regulator of infectivity in malaria parasite sporozoite stages [J].

Aly, Ahmed S. I. ;

Lindner, Scott E. ;

MacKellar, Drew C. ;

Peng, Xinxia ;

Kappe, Stefan H. I. .

MOLECULAR MICROBIOLOGY, 2011, 79 (04) :929-939

[4] Two Plasmodium 6-Cys family-related proteins have distinct and critical roles in liver-stage development [J].

Annoura, Takeshi ;

van Schaijk, Ben C. L. ;

Ploemen, Ivo H. J. ;

Sajid, Mohammed ;

Lin, Jing-wen ;

Vos, Martijn W. ;

Dinmohamed, Avinash G. ;

Inaoka, Daniel K. ;

Rijpma, Sanna R. ;

van Gemert, Geert-Jan ;

Chevalley-Maurel, Severine ;

Kielbasa, Szymon M. ;

Scheltinga, Fay ;

Franke-Fayard, Blandine ;

Klop, Onny ;

Hermsen, Cornelus C. ;

Kita, Kiyoshi ;

Gego, Audrey ;

Franetich, Jean-Francois ;

Mazier, Dominique ;

Hoffman, Stephen L. ;

Janse, Chris J. ;

Sauerwein, Robert W. ;

Khan, Shahid M. .

FASEB JOURNAL, 2014, 28 (05) :2158-2170

[5] Assessing the adequacy of attenuation of genetically modified malaria parasite vaccine candidates [J].

Annoura, Takeshi ;

Ploemen, Ivo H. J. ;

van Schaijk, Ben C. L. ;

Sajid, Mohammed ;

Vos, Martijn W. ;

van Gemert, Geert-Jan ;

Chevalley-Maurel, Severine ;

Franke-Fayard, Blandine M. D. ;

Hermsen, Cornelus C. ;

Gego, Audrey ;

Franetich, Jean-Francois ;

Mazier, Dominique ;

Hoffman, Stephen L. ;

Janse, Chris J. ;

Sauerwein, Robert W. ;

Khan, Shahid M. .

VACCINE, 2012, 30 (16) :2662-2670

[6]

[Anonymous], 2014, World Malaria Report

[7]

BEAUDOIN RL, 1977, EXP PARASITOL, V42, P1, DOI 10.1016/0014-4894(77)90054-6

[8] Sporozoite immunization of human volunteers under chemoprophylaxis induces functional antibodies against pre-erythrocytic stages of Plasmodium falciparum [J].

Behet, Marije C. ;

Foquet, Lander ;

van Gemert, Geert-Jan ;

Bijker, Else M. ;

Meuleman, Philip ;

Leroux-Roels, Geert ;

Hermsen, Cornelus C. ;

Scholzen, Anja ;

Sauerwein, Robert W. .

MALARIA JOURNAL, 2014, 13

[9] Protective T cell immunity against malaria liver stage after vaccination with live sporozoites under chloroquine treatment [J].

Belnoue, E ;

Costa, FTM ;

Frankenberg, T ;

Vigário, AM ;

Voza, T ;

Leroy, N ;

Rodrigues, MM ;

Landau, I ;

Snounou, G ;

Rénia, L .

JOURNAL OF IMMUNOLOGY, 2004, 172 (04) :2487-2495

[10] Sporozoite Immunization of Human Volunteers under Mefloquine Prophylaxis Is Safe, Immunogenic and Protective: A Double-Blind Randomized Controlled Clinical Trial [J].

Bijker, Else M. ;

Schats, Remko ;

Obiero, Joshua M. ;

Behet, Marije C. ;

van Gemert, Geert-Jan ;

de Vegte-Bolmer, Marga van ;

Graumans, Wouter ;

van Lieshout, Lisette ;

Bastiaens, Guido J. H. ;

Teelen, Karina ;

Hermsen, Cornelus C. ;

Scholzen, Anja ;

Visser, Leo G. ;

Sauerwein, Robert W. .

PLOS ONE, 2014, 9 (11)

← 1 2 3 4 5 6 7 8 9 →