Novel method for genotyping clinical herpes simplex virus type 1 isolates (vol 160, pg 2807, 2015)

被引：0

作者：

Glueck, Brigitte ^{[1
]}

Moebius, Susanne ^{[1
]}

Pfaff, Florian ^{[1
]}

Zell, Roland ^{[1
]}

Sauerbrei, Andreas ^{[1
]}

机构：

[1] Univ Jena, Jena Univ Hosp, Inst Virol & Antiviral Therapy, German Consulting Lab HSV & VZV, D-07745 Jena, Germany

来源：

ARCHIVES OF VIROLOGY | 2015年 / 160卷 / 11期

关键词：

Herpes Labialis; Restriction Fragment Length Polymorphism Assay; Herpes Simplex Virus Genome; Eczema Herpeticum; Intergenic Recombinant;

D O I：

10.1007/s00705-015-2601-1

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Up to now, three distinct genotypes, A, B and C, of herpes simplex virus type 1 (HSV-1), based on polymorphisms in the US4 and US7 genes, have been reported. Here, we propose to include an additional polymorphism of the US2 gene. The refined genotyping method was validated using 423 clinical isolates from patients with different HSV-1 diseases. The proportions of three US2 genotypes were A, 46.6 %; B, 23.2 %; and C, 30.2 %. Genotype A of US2 and US4/US7 showed a highly significant correlation. In addition, the frequency of genotype A was significantly higher in women than in men with herpes labialis.

引用

页码：2813 / 2814

页数：2