The biological significance of lipid-protein interactions

被引：27

作者：

Findlay, HE ^{[1
]}

Booth, PJ ^{[1
]}

机构：

[1] Univ Bristol, Dept Biochem, Bristol BS8 1TD, Avon, England

来源：

JOURNAL OF PHYSICS-CONDENSED MATTER | 2006年 / 18卷 / 28期

关键词：

D O I：

10.1088/0953-8984/18/28/S11

中图分类号：

O469 [凝聚态物理学];

学科分类号：

070205 ;

摘要：

Biological membranes are complex environments, where membrane proteins are surrounded by a bilayer composed of many different types of lipid. The physical properties of the bilayer influence protein structure, folding and function, while specific interactions with lipid molecules can also contribute towards the biological activity of some membrane proteins. Improving understanding of these interactions has resulted in the development of synthetic lipid systems that allow the bilayer properties to be rationally manipulated in vitro to control protein behaviour.

引用

页码：S1281 / S1291

页数：11

共 68 条

[1] The role of cholesterol in rod outer segment membranes [J].

Albert, AD ;

Boesze-Battaglia, K .

PROGRESS IN LIPID RESEARCH, 2005, 44 (2-3) :99-124

[2] Effect of cholesterol on rhodopsin stability in disk membranes [J].

Albert, AD ;

BoeszeBattaglia, K ;

Paw, Z ;

Watts, A ;

Epand, RM .

BIOCHIMICA ET BIOPHYSICA ACTA-PROTEIN STRUCTURE AND MOLECULAR ENZYMOLOGY, 1996, 1297 (01) :77-82

[3] Controlling the folding efficiency of an integral membrane protein [J].

Allen, SJ ;

Curran, AR ;

Templer, RH ;

Meijberg, W ;

Booth, PJ .

JOURNAL OF MOLECULAR BIOLOGY, 2004, 342 (04) :1293-1304

[4]

[Anonymous], 1997, FLATLAND GEOMETRIC F, DOI DOI 10.1016/B978-044481538-5/50005-8

[5] Modulation of CTP:phosphocholine cytidylyltransferase by membrane curvature elastic stress [J].

Attard, GS ;

Templer, RH ;

Smith, WS ;

Hunt, AN ;

Jackowski, S .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (16) :9032-9036

[6] Protein, lipid and water organization in bacteriorhodopsin crystals:: a molecular view of the purple membrana at 1.9 Å resolution [J].

Belrhali, H ;

Nollert, P ;

Royant, A ;

Menzel, C ;

Rosenbusch, JP ;

Landau, EM ;

Pebay-Peyroula, E .

STRUCTURE, 1999, 7 (08) :909-917

[7] A polytopic membrane protein displays a reversible topology dependent on membrane lipid composition [J].

Bogdanov, M ;

Heacock, PN ;

Dowhan, W .

EMBO JOURNAL, 2002, 21 (09) :2107-2116

[8] Phospholipid-assisted protein folding: phosphatidylethanolamine is required at a late step of the conformational maturation of the polytopic membrane protein lactose permease [J].

Bogdanov, M ;

Dowhan, W .

EMBO JOURNAL, 1998, 17 (18) :5255-5264

[9] Same in the membrane: designing systems to modulate membrane proteins [J].

Booth, PJ .

CURRENT OPINION IN STRUCTURAL BIOLOGY, 2005, 15 (04) :435-440

[10] The aromatic residues Trp and Phe have different effects on the positioning of a transmembrane helix in the microsomal membrane [J].

Braun, P ;

von Heijne, G .

BIOCHEMISTRY, 1999, 38 (30) :9778-9782

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