A review of organophosphorus flame retardants (OPFRs): occurrence, bioaccumulation, toxicity, and organism exposure

被引：146

作者：

Du, Jia ^{[1
]}

Li, Huanxuan ^{[1
]}

Xu, Shaodan ^{[1
]}

Zhou, Qingwei ^{[1
]}

Jin, Meiqing ^{[1
]}

Tang, Junhong ^{[1
]}

机构：

[1] Hangzhou Dianzi Univ, Coll Mat & Environm Engn, Inst Environm Sci & Engn, 1158 Baiyang Rd, Hangzhou 310018, Zhejiang, Peoples R China

来源：

ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH | 2019年 / 26卷 / 22期

关键词：

Organophosphorus flame retardants; In vitro toxicity; In vivo toxicity; Bioaccumulation; Biomagnification; MESSENGER-RNA EXPRESSION; TRIS(1,3-DICHLORO-2-PROPYL) PHOSPHATE; TRIPHENYL PHOSPHATE; WASTE-WATER; OXIDATIVE STRESS; TREATMENT-PLANT; INDOOR DUST; PLASTICIZERS; TDCPP; METABOLISM;

D O I：

10.1007/s11356-019-05669-y

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Organophosphorus flame retardants (OPFRs) are increasingly being applied as flame retardants due to their unique properties. OPFRs are commonly detected in various environmental matrices, and organisms are extensively exposed to them. Considering the adverse effects of OPFRs, many researchers have devoted their attention to environmental risk assessments. This review outlines the current knowledge regarding the toxicity of OPFRs based on both in vitro and in vivo experiments in various environmentally relevant test species. The production, absorption, bioaccumulation, and biomagnification of OPFRs in animals and humans are also described. The joint effects of OPFRs and their coexisting characteristics are also discussed based on the limited available data and results. Finally, knowledge gaps and perspectives for future exposure studies of OPFRs in animals and humans are identified.

引用

页码：22126 / 22136

页数：11

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