The effect of CP-96,345, a non-peptide substance-P antagonist, on thermoregulation and the development of endotoxin-fever in rats

被引：8

作者：

Balaskó, M ^{[1
]}

Székely, M ^{[1
]}

Szelényi, Z ^{[1
]}

机构：

[1] Univ Pecs, Sch Med, Dept Pathophysiol, Pecs, Hungary

来源：

JOURNAL OF THERMAL BIOLOGY | 2000年 / 25卷 / 1-2期

关键词：

endotoxin; fever; substance-P; CP-96,345; substance-P non-peptide antagonist; thermoregulation;

D O I：

10.1016/S0306-4565(99)00035-2

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

1. Substance-P (SP) has been shown to induce a regulated rise in body temperature when injected into one of the lateral cerebral ventricles of rats. 2. The non-peptide antagonist of SP (CP-96,345) decreased the SP-induced rise in core temperature and, when given prior to an intravenous endotoxin injection, it also attenuated the febrile response to endotoxin. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：1 / 4

页数：4

共 13 条

[1]

BLATTEIS CM, 1994, ANN NY ACAD SCI, V741, P162, DOI 10.1111/j.1749-6632.1994.tb23097.x

[2] LACK OF POTENT ANTINOCICEPTIVE ACTIVITY BY SUBSTANCE-P ANTAGONIST CP-96,345 IN THE RAT SPINAL-CORD [J].