Catalyst-free reductive amination of levulinic acid to N-substituted pyrrolidinones with formic acid in continuous-flow microreactor

被引：18

作者：

Ma, Tengfei ^{[1
]}

Zhang, Hong-Yu ^{[1
]}

Yin, Guohui ^{[1
]}

Zhao, Jiquan ^{[1
]}

Zhang, Yuecheng ^{[1
,2
]}

机构：

[1] Hebei Univ Technol, Sch Chem Engn & Technol, Tianjin 300130, Peoples R China

[2] Hebei Univ Technol, Natl Local Joint Engn Lab Energy Conservat Chem P, Tianjin 300130, Peoples R China

来源：

JOURNAL OF FLOW CHEMISTRY | 2018年 / 8卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Continuous-flow microreactor; Levulinic acid; Amines; Reductive amination; N-substituted pyrrolidinones; MICRO-REACTORS; PYRROLIDONE DERIVATIVES; LIGNOCELLULOSIC BIOMASS; ETHYL LEVULINATE; HIGHLY EFFICIENT; PYRIDINE BASES; CONVERSION; HYDROGENATION; TECHNOLOGY; TRANSFORMATION;

D O I：

10.1007/s41981-018-0005-6

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The reductive amination of levulinic acid to N-substituted pyrrolidinones was performed in a continuous-flow microreactor (CFMR) in high yield, using formic acid as hydrogen source and acetonitrile as the reaction solvent. The developed protocol allows the avoidance of high boiling solvents such as DMSO and the additive triethylamine, more commonly associated with this synthetic transformation. As a result, the reaction products are more readily separated from the low boiling solvent.

引用

页码：35 / 43

页数：9

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