LncRNA PACER is down-regulated in osteoarthritis and regulates chondrocyte apoptosis and lncRNA HOTAIR expression

被引：33

作者：

Jiang, Mingwei ^{[1
]}

Liu, Jie ^{[2
]}

Luo, Tao ^{[1
]}

Chen, Qiu ^{[1
]}

Lu, Ming ^{[1
]}

Meng, Deqiang ^{[1
]}

机构：

[1] Shanghai Publ Hlth Clin Ctr, Dept Orthopaed, Shanghai 201508, Peoples R China

[2] Hangzhou First Peoples Hosp, Dept Orthopaed, Hangzhou 310006, Zhejiang, Peoples R China

来源：

BIOSCIENCE REPORTS | 2019年 / 39卷

关键词：

LONG NONCODING RNAS;

D O I：

10.1042/BSR20190404

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

LncRNA PACER is a chondrocyte inflammation-associated long non-coding RNA (lncRNA), and chondrocyte inflammation is involved in osteoarthritis (OA). We observed that plasma PACER was down-regulated, while plasma HOTAIR was up-regulated in OA patients. Altered plasma levels of PACER and HOTAIR distinguished OA patients from healthy controls. PACER and HOTAIR were inversely correlated in both OA patients and healthy controls. PACER overexpression mediated the down-regulation of HOTAIR, while HOTAIR overexpression did not significantly affect PACER. PACER overexpression led to inhibited, while HOTAIR overexpression led to promoted apoptosis of chondrocyte. HOTAIR overexpression attenuated the effects of PACER overexpression. Therefore, lncRNA PACER is down-regulated in OA and regulates chondrocyte apoptosis by down-regulating lncRNA HOTAIR.

引用

页数：7

共 18 条

[1]

[Anonymous], 2014, PLOS ONE

[2] LncRNA HOTAIR: A master regulator of chromatin dynamics and cancer [J].

Bhan, Arunoday ;

Mandal, Subhrangsu S. .

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER, 2015, 1856 (01) :151-164

[3] HOTAIR: a cancer-related long non-coding RNA [J].

Cai, B. ;

Song, X. Q. ;

Cai, J. P. ;

Zhang, S. .

NEOPLASMA, 2014, 61 (04) :379-391

[4] Long non-coding RNAs and complex diseases: from experimental results to computational models [J].

Chen, Xing ;

Yan, Chenggang Clarence ;

Zhang, Xu ;

You, Zhu-Hong .

BRIEFINGS IN BIOINFORMATICS, 2017, 18 (04) :558-576

[5] Long non-coding RNAs: spatial amplifiers that control nuclear structure and gene expression [J].

Engreitz, Jesse M. ;

Ollikainen, Noah ;

Guttman, Mitchell .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2016, 17 (12) :756-770

[6] Differential transcriptome analysis of intraarticular les ona vs intact cartilage reveals new candidate genes in osteoarthritis pathophysiology [J].

Geyer, M. ;

Graessel, S. ;

Straub, R. H. ;

Schett, G. ;

Dinser, R. ;

Grifka, J. ;

Gay, S. ;

Neumann, E. ;

Mueller-Ladner, U. .

OSTEOARTHRITIS AND CARTILAGE, 2009, 17 (03) :328-335

[7] Osteoarthritis as a public health problem: the impact of developing knee pain on physical function in adults living in the community: (KNEST 3) [J].

Jinks, C. ;

Jordan, K. ;

Croft, P. .

RHEUMATOLOGY, 2007, 46 (05) :877-881

[8] Emerging regulators of the inflammatory process in osteoarthritis [J].

Liu-Bryan, Ru ;

Terkeltaub, Robert .

NATURE REVIEWS RHEUMATOLOGY, 2015, 11 (01) :35-44

[9] Noncoding RNAs, cytokines, and inflammation-related diseases [J].

Marques-Rocha, Jose Luiz ;

Samblas, Mirian ;

Milagro, Fermin I. ;

Bressan, Josefina ;

Alfredo Martinez, J. ;

Marti, Amelia .

FASEB JOURNAL, 2015, 29 (09) :3595-3611

[10] Long Intergenic Noncoding RNAs Mediate the Human Chondrocyte Inflammatory Response and Are Differentially Expressed in Osteoarthritis Cartilage [J].

Pearson, Mark J. ;

Philp, Ashleigh M. ;

Heward, James A. ;

Roux, Benoit T. ;

Walsh, David A. ;

Davis, Edward T. ;

Lindsay, Mark A. ;

Jones, Simon W. .

ARTHRITIS & RHEUMATOLOGY, 2016, 68 (04) :845-856

← 1 2 →