PI 3-kinase and cancer: changing accents

被引：71
|
作者：
Vogt, Peter K. [1 ]
Gymnopoulos, Marco [1 ]
Hart, Jonathan R. [1 ]
机构：
[1] Scripps Res Inst, Dept Mol & Expt Med, Div Oncovirol, La Jolla, CA 92037 USA
来源：
CURRENT OPINION IN GENETICS & DEVELOPMENT | 2009年 / 19卷 / 01期
关键词：
PHOSPHATIDYLINOSITOL KINASE-ACTIVITY; PHOSPHOINOSITIDE; 3-KINASE; PIK3CA MUTATIONS; CELL-GROWTH; P110-DELTA; P110-BETA; ISOFORM; GENE; PATHWAY; PROTEIN;
D O I：
10.1016/j.gde.2008.11.011
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Research on PI 3-kinase (PI3K) is undergoing significant shifts in emphasis. Questions that have been dormant for some time are coming to the forefront, such as the relationship of PTEN to PI3K and the role of AKT in PI3K-driven oncogenesis. Two non-alpha isoforms of Class I PI3K are now established as important determinants in cancer: p110 beta and p110 delta. The oncogenic activities of p110 beta include a non-catalytic function, a finding that will have immediate consequences for drug development.
引用
收藏
页码：12 / 17
页数：6
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