Human relevance of NRAS/BRAF mouse melanoma models

被引：12

作者：

Conde-Perez, Alejandro ^{[1
,2
,3
]}

Larue, Lionel ^{[1
,2
,3
]}

机构：

[1] Inst Curie, F-91405 Orsay, France

[2] CNRS, UMR3347, F-75700 Paris, France

[3] INSERM, U1021, F-75654 Paris 13, France

来源：

EUROPEAN JOURNAL OF CELL BIOLOGY | 2014年 / 93卷 / 1-2期

关键词：

PTEN; beta-Catenin; p16(INK4A); Melanomagenesis; Initiation; Progression; BETA-CATENIN; CUTANEOUS MELANOMA; GENERAL STRATEGY; PTEN; BRAF; MUTATIONS; EXPRESSION; SENESCENCE; PATHWAYS; SKIN;

D O I：

10.1016/j.ejcb.2013.10.010

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Melanoma is a major problem for many individuals worldwide. Although no effective treatment is available, promising new strategies are being developed. A better understanding of the inner workings of the disease would undoubtedly lead to improved treatments. Mouse melanoma models have been used to elucidate many key regulatory pathways involved in melanoma initiation and progression, and models with mutations in the oncogenes RAF and RAS have been particularly informative. Here, we summarize and evaluate the human relevance of various RAF and RAS mouse melanoma models and their contribution to our understanding of melanoma. (C) 2013 Elsevier GmbH. All rights reserved.

引用

页码：82 / 86

页数：5

共 48 条

[31] High-throughput sequencing of the melanoma genome [J].

Kunz, Manfred ;

Dannemann, Michael ;

Kelso, Janet .

EXPERIMENTAL DERMATOLOGY, 2013, 22 (01) :10-17

[32] Cutaneous melanoma in genetically modified animals [J].

Larue, Lionel ;

Beermann, Friedrich .

PIGMENT CELL RESEARCH, 2007, 20 (06) :485-497

[33] Biological and mathematical modeling of melanocyte development [J].

Luciani, Flavie ;

Champeval, Delphine ;

Herbette, Aurelie ;

Denat, Laurence ;

Aylaj, Bouchra ;

Martinozzi, Silvia ;

Ballotti, Robert ;

Kemler, Rolf ;

Goding, Colin R. ;

De Vuyst, Florian ;

Larue, Lionel ;

Delmas, Veronique .

DEVELOPMENT, 2011, 138 (18) :3943-3954

[34] Elucidating Distinct Roles for NF1 in Melanomagenesis [J].

Maertens, Ophelia ;

Johnson, Bryan ;

Hollstein, Pablo ;

Frederick, Dennie T. ;

Cooper, Zachary A. ;

Messiaen, Ludwine ;

Bronson, Roderick T. ;

McMahon, Martin ;

Granter, Scott ;

Flaherty, Keith ;

Wargo, Jennifer A. ;

Marais, Richard ;

Cichowski, Karen .

CANCER DISCOVERY, 2013, 3 (03) :338-349

[35] BRAFE600-associated senescence-like cell cycle arrest of human naevi [J].

Michaloglou, C ;

Vredeveld, LCW ;

Soengas, MS ;

Denoyelle, C ;

Kuilman, T ;

van der Horst, CMAM ;

Majoor, DM ;

Shay, JW ;

Mooi, WJ ;

Peeper, DS .

NATURE, 2005, 436 (7051) :720-724

[36] Somatic p16INK4a loss accelerates melanomagenesis [J].

Monahan, K. B. ;

Rozenberg, G. I. ;

Krishnamurthy, J. ;

Johnson, S. M. ;

Liu, W. ;

Bradford, M. K. ;

Horner, J. ;

DePinho, R. A. ;

Sharpless, N. E. .

ONCOGENE, 2010, 29 (43) :5809-5817

[37] Exome sequencing identifies recurrent somatic MAP2K1 and MAP2K2 mutations in melanoma [J].

Nikolaev, Sergey I. ;

Rimoldi, Donata ;

Iseli, Christian ;

Valsesia, Armand ;

Robyr, Daniel ;

Gehrig, Corinne ;

Harshman, Keith ;

Guipponi, Michel ;

Bukach, Olesya ;

Zoete, Vincent ;

Michielin, Olivier ;

Muehlethaler, Katja ;

Speiser, Daniel ;

Beckmann, Jacques S. ;

Xenarios, Ioannis ;

Halazonetis, Thanos D. ;

Jongeneel, C. Victor ;

Stevenson, Brian J. ;

Antonarakis, Stylianos E. .

NATURE GENETICS, 2012, 44 (02) :133-139

[38] Cooperative interactions of PTEN deficiency and RAS activation in melanoma metastasis [J].

Nogueira, C. ;

Kim, K-H ;

Sung, H. ;

Paraiso, K. H. T. ;

Dannenberg, J-H ;

Bosenberg, M. ;

Chin, L. ;

Kim, M. .

ONCOGENE, 2010, 29 (47) :6222-6232

[39] Frequent Nuclear/Cytoplasmic localization of β-catenin without exon 3 mutations in malignant melanoma [J].

Rimm, DL ;

Caca, K ;

Hu, G ;

Harrison, FB ;

Fearon, ER .

AMERICAN JOURNAL OF PATHOLOGY, 1999, 154 (02) :325-329

[40] Cancer statistics for Hispanics/Latinos, 2012 [J].

Siegel, Rebecca ;

Naishadham, Deepa ;

Jemal, Ahmedin .

CA-A CANCER JOURNAL FOR CLINICIANS, 2012, 62 (05) :283-298

← 1 2 3 4 5 →