Human relevance of NRAS/BRAF mouse melanoma models

被引：13

作者：

Conde-Perez, Alejandro ^{[1
,2
,3
]}

Larue, Lionel ^{[1
,2
,3
]}

机构：

[1] Inst Curie, F-91405 Orsay, France

[2] CNRS, UMR3347, F-75700 Paris, France

[3] INSERM, U1021, F-75654 Paris 13, France

来源：

EUROPEAN JOURNAL OF CELL BIOLOGY | 2014年 / 93卷 / 1-2期

关键词：

PTEN; beta-Catenin; p16(INK4A); Melanomagenesis; Initiation; Progression; BETA-CATENIN; CUTANEOUS MELANOMA; GENERAL STRATEGY; PTEN; BRAF; MUTATIONS; EXPRESSION; SENESCENCE; PATHWAYS; SKIN;

D O I：

10.1016/j.ejcb.2013.10.010

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Melanoma is a major problem for many individuals worldwide. Although no effective treatment is available, promising new strategies are being developed. A better understanding of the inner workings of the disease would undoubtedly lead to improved treatments. Mouse melanoma models have been used to elucidate many key regulatory pathways involved in melanoma initiation and progression, and models with mutations in the oncogenes RAF and RAS have been particularly informative. Here, we summarize and evaluate the human relevance of various RAF and RAS mouse melanoma models and their contribution to our understanding of melanoma. (C) 2013 Elsevier GmbH. All rights reserved.

引用

页码：82 / 86

页数：5

共 48 条

[1] Metastasizing melanoma formation caused by expression of activated N-RasQ61K on an INK4a-deficient background [J].

Ackermann, J ;

Frutschi, M ;

Kaloulis, K ;

McKee, T ;

Trumpp, A ;

Beermann, F .

CANCER RESEARCH, 2005, 65 (10) :4005-4011

[2] Final Version of 2009 AJCC Melanoma Staging and Classification [J].

Balch, Charles M. ;

Gershenwald, Jeffrey E. ;

Soong, Seng-jaw ;

Thompson, John F. ;

Atkins, Michael B. ;

Byrd, David R. ;

Buzaid, Antonio C. ;

Cochran, Alistair J. ;

Coit, Daniel G. ;

Ding, Shouluan ;

Eggermont, Alexander M. ;

Flaherty, Keith T. ;

Gimotty, Phyllis A. ;

Kirkwood, John M. ;

McMasters, Kelly M. ;

Mihm, Martin C., Jr. ;

Morton, Donald L. ;

Ross, Merrick I. ;

Sober, Arthur J. ;

Sondak, Vernon K. .

JOURNAL OF CLINICAL ONCOLOGY, 2009, 27 (36) :6199-6206

[3] Dual inactivation of RB and p53 pathways in RAS-induced melanomas [J].

Bardeesy, N ;

Bastian, BC ;

Hezel, A ;

Pinkel, D ;

DePinho, RA ;

Chin, L .

MOLECULAR AND CELLULAR BIOLOGY, 2001, 21 (06) :2144-2153

[4] Classifying melanocytic tumors based on DNA copy number changes [J].

Bastian, BC ;

Olshen, AB ;

LeBoit, PE ;

Pinkel, D .

AMERICAN JOURNAL OF PATHOLOGY, 2003, 163 (05) :1765-1770

[5] Congenital melanocytic nevi frequently harbor NRAS mutations but no BRAF mutations [J].

Bauer, Juergen ;

Curtin, John A. ;

Pinkel, Dan ;

Bastian, Boris C. .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2007, 127 (01) :179-182

[6] General strategy to analyse coat colour phenotypes in mice [J].

Berlin, Irina ;

Luciani, Flavie ;

Gallagher, Stuart J. ;

Rambow, Florian ;

Conde-Perez, Alejandro ;

Colombo, Sophie ;

Champeval, Delphine ;

Delmas, Veronique ;

Larue, Lionel .

PIGMENT CELL & MELANOMA RESEARCH, 2012, 25 (01) :117-119

[7] Characterization of melanocyte-specific inducible Cre recombinase transgenic mice [J].

Bosenberg, M ;

Muthusamy, V ;

Curley, DR ;

Wang, ZX ;

Hobbs, C ;

Nelson, B ;

Nogueira, C ;

Horner, JW ;

DePinho, R ;

Chin, L .

GENESIS, 2006, 44 (05) :262-267

[8] Safety and Activity of Anti-PD-L1 Antibody in Patients with Advanced Cancer [J].

Brahmer, Julie R. ;

Tykodi, Scott S. ;

Chow, Laura Q. M. ;

Hwu, Wen-Jen ;

Topalian, Suzanne L. ;

Hwu, Patrick ;

Drake, Charles G. ;

Camacho, Luis H. ;

Kauh, John ;

Odunsi, Kunle ;

Pitot, Henry C. ;

Hamid, Omid ;

Bhatia, Shailender ;

Martins, Renato ;

Eaton, Keith ;

Chen, Shuming ;

Salay, Theresa M. ;

Alaparthy, Suresh ;

Grosso, Joseph F. ;

Korman, Alan J. ;

Parker, Susan M. ;

Agrawal, Shruti ;

Goldberg, Stacie M. ;

Pardoll, Drew M. ;

Gupta, Ashok ;

Wigginton, Jon M. .

NEW ENGLAND JOURNAL OF MEDICINE, 2012, 366 (26) :2455-2465

[9] Modeling malignant melanoma in mice: pathogenesis and maintenance [J].

Chin, L .

ONCOGENE, 1999, 18 (38) :5304-5310

[10] β-Catenin Signaling Controls Metastasis in Braf-Activated Pten-Deficient Melanomas [J].

Damsky, William E. ;

Curley, David P. ;

Santhanakrishnan, Manjula ;

Rosenbaum, Lara E. ;

Platt, James T. ;

Rothberg, Bonnie E. Gould ;

Taketo, Makoto M. ;

Dankort, David ;

Rimm, David L. ;

McMahon, Martin ;

Bosenberg, Marcus .

CANCER CELL, 2011, 20 (06) :741-754

← 1 2 3 4 5 →