Targeting Autophagy in Breast Cancer

被引：81

作者：

Cocco, Stefania ^{[1
]}

Leone, Alessandra ^{[2
]}

Piezzo, Michela ^{[1
]}

Caputo, Roberta ^{[1
]}

Di Lauro, Vincenzo ^{[1
]}

Di Rella, Francesca ^{[1
]}

Fusco, Giuseppina ^{[1
]}

Capozzi, Monica ^{[1
]}

di Gioia, Germira ^{[1
]}

Budillon, Alfredo ^{[2
]}

De Laurentiis, Michelino ^{[1
]}

机构：

[1] Ist Nazl Tumori IRCCS Fdn G Pascale, Breast Unit, Via Mariano Semmola 53, I-80131 Naples, Italy

[2] Ist Nazl Tumori IRCCS Fdn G Pascale, Expt Pharmacol Unit, Via Mariano Semmola 53, I-80131 Naples, Italy

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2020年 / 21卷 / 21期

关键词：

breast cancer; autophagy; ATG; Chloroquine; Hydroxychloroquine; ACD; EPITHELIAL-MESENCHYMAL TRANSITION; HYPOXIA-INDUCIBLE FACTORS; CELL-DEATH; STEM-CELLS; CISPLATIN RESISTANCE; OVARIAN-CANCER; SUPPRESSES PROLIFERATION; HEPATOCELLULAR-CARCINOMA; MOLECULAR-MECHANISM; SELECTIVE AUTOPHAGY;

D O I：

10.3390/ijms21217836

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Breast cancer is a heterogeneous disease consisting of different biological subtypes, with differences in terms of incidence, response to diverse treatments, risk of disease progression, and sites of metastases. In the last years, several molecular targets have emerged and new drugs, targeting PI3K/Akt/mTOR and cyclinD/CDK/pRb pathways and tumor microenvironment have been integrated into clinical practice. However, it is clear now that breast cancer is able to develop resistance to these drugs and the identification of the underlying molecular mechanisms is paramount to drive further drug development. Autophagy is a highly conserved homeostatic process that can be activated in response to antineoplastic agents as a cytoprotective mechanism. Inhibition of autophagy could enhance tumor cell death by diverse anti-cancer therapies, representing an attractive approach to control mechanisms of drug resistance. In this manuscript, we present a review of autophagy focusing on its interplay with targeted drugs used for breast cancer treatment.

引用

页码：1 / 22

页数：21

共 183 条

[1] Chloroquine synergizes sunitinib cytotoxicity via modulating autophagic, apoptotic and angiogenic machineries [J].