Strain Variation and Disease Severity in Congenital Cytomegalovirus Infection: In Search of a Viral Marker

被引:34
作者
Arav-Boger, Ravit [1 ]
机构
[1] Johns Hopkins Univ, Sch Med, Dept Pediat, Div Infect Dis, Baltimore, MD 21287 USA
关键词
Cytomegalovirus; Congenital infection; Strains; Genotypes; Multiple strains; Immune evasion genes; Population-based sequencing; Next-generation sequencing; RENAL-TRANSPLANT RECIPIENTS; POLYMERASE-CHAIN-REACTION; GLYCOPROTEIN-N GN; SEQUENCE VARIABILITY; MOLECULAR EPIDEMIOLOGY; GENOTYPIC DIVERSITY; GENES; UL144; CHILDREN; ALPHA;
D O I
10.1016/j.idc.2015.05.009
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The wide spectrum of congenital cytomegalovirus (CMV) disease and known differences in the biology and in vitro growth of CMV strains continue to drive studies in search for specific viral genetic determinants that may predict severity of congenital CMV disease. Several CMV genes have been studied in detail in congenitally infected children, but the complexity of the viral genome and differences in the definition of symptomatic disease versus asymptomatic CMV infection continue to raise questions related to what constitutes a pathogenic CMV strain.
引用
收藏
页码:401 / +
页数:15
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