Reprint of "EXOSOME LEVELS IN HUMAN BODY FLUIDS: A TUMOR MARKER BY THEMSELVES?"

被引：5

作者：

Cappello, Francesco ^{[1
,2
]}

Logozzi, Mariantonia ^{[3
]}

Campanella, Claudia ^{[1
,2
]}

Bavisotto, Celeste Caruso ^{[1
,2
]}

Marcilla, Antonio ^{[4
,5
]}

Properzi, Francesca ^{[3
]}

Fais, Stefano ^{[3
]}

机构：

[1] Univ Palermo, Dept Expt Biomed & Clin Neurosci, Palermo, Italy

[2] Euromediterranean Inst Sci & Technol, Palermo, Italy

[3] Natl Inst Hlth, Dept Therapeut Res & Med Evaluat, Rome, Italy

[4] Univ Valencia, Area Parasitol, Dept Biol Cellular & Parasitol, Valencia, Spain

[5] Univ Valencia, Joint Res Unit Endocrinol Nutr & Clin Dietet, Hlth Res Inst La Fe, Valencia, Spain

来源：

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES | 2017年 / 98卷

关键词：

Extracellular vesicles; Exosomes; Biomarkers; Body fluids; Early diagnosis; Follow-up; Prostate cancer; EXTRACELLULAR VESICLES; PROSTATE-CANCER; MELANOMA EXOSOMES; PROGENITOR CELLS; BIOMARKERS; MICROVESICLES; KIDNEY; SERUM; RELEASE; BREAST;

D O I：

10.1016/j.ejps.2016.11.007

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Despite considerable research efforts, the finding of reliable tumor biomarkers remains challenging and unresolved. In recent years a novel diagnostic biomedical tool with high potential has been identified in extracellular nanovesicles or exosomes. They are released by the majority of the cells and contain detailed molecular information on the cell of origin including tumor hallmarks. Exosomes can be isolated from easy accessible body fluids, and most importantly, they can at once provide with several biomarkers, with different levels of specificity. Recent clinical evidence shows that the levels of exosomes released into body fluids may by themselves represent a predictive/diagnostic of tumors, discriminating cancer patients from healthy subjects. The aim of this review is to highlight these latest challenging findings to provide novel and groundbreaking ideas for successful tumor early diagnosis and follow-up. (C) 2016 Elsevier B.V. All rights reserved.

引用

页码：64 / 69

页数：6

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