Building Addressable Libraries: Site-Selective Suzuki Reactions on Microelectrode Arrays

被引：32

作者：

Hu, Libo ^{[1
]}

Maurer, Karl ^{[2
]}

Moeller, Kevin D. ^{[1
]}

机构：

[1] Washington Univ, Dept Chem, St Louis, MO 63130 USA

[2] CombiMatrix Corp, Mukilteo, WA 98275 USA

来源：

ORGANIC LETTERS | 2009年 / 11卷 / 06期

基金：

美国国家科学基金会;

关键词：

ELECTROCHEMISTRY; TOOLS;

D O I：

10.1021/ol900056u

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A site-selective Suzuki reaction has been developed for use on microelectrode arrays. The reaction conditions employed are similar to those used to achieve site-selective Heck reactions. The reaction can be run with either an aryliodide attached to the surface of the array and an arylboronic acid in solution or with an arylboronic acid attached to the surface of the array and an arylbromide in solution. Both allyl acetate and air are effective confining agents for the reaction, The reactions are compatible with arrays containing either 1024 microelectrodes cm(-2) or 12 544 microelectrodes cm(-2).

引用

页码：1273 / 1276

页数：4

共 25 条

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