Nuclear translocation of NF-kappa B in cholinergic neurons of patients with Alzheimer's disease

被引:146
作者
Boissiere, F [1 ]
Hunot, S [1 ]
Faucheux, B [1 ]
Duyckaerts, C [1 ]
Hauw, JJ [1 ]
Agid, Y [1 ]
Hirsch, EC [1 ]
机构
[1] HOP LA PITIE SALPETRIERE,LAB NEUROPATHOL R ESCOUROLLE,F-75013 PARIS,FRANCE
关键词
Alzheimer's disease; immunohistochemistry; nucleus basalis of Meynert; nuclear factor-kappa B;
D O I
10.1097/00001756-199709080-00009
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
NF-kappa B is a nuclear transcription factor involved in the control of numerous cellular functions, particularly regulation of survival. Translocation from the cytoplasm to the nucleus, an event essential for NK-kappa B activation, could be mediated through the low-affinity nerve growth factor receptor, p75, which has recently been shown to mediate cell death. In the human brain, p75 is exclusively expressed in cholinergic neurons of the basal forebrain. This population degenerates in Alzheimer's disease (AD). To investigate whether p75 could play a role in the vulnerability of these neurons via NF-kappa B activation, we studied the cellular distribution of NF-kappa B in the nucleus basalis of Meynert of four AD patients and four control subjects. The immunostaining observed both in AD patients and control subjects was limited to large, probably cholinergic, neurons. In AD, the proportion of neurons with nuclear NF-kappa B staining was significantly increased, suggesting an association between NF-kappa B functions and the process of cholinergic degeneration in AD.
引用
收藏
页码:2849 / 2852
页数:4
相关论文
共 23 条
[1]  
BAEURELE PA, 1994, NATURE, V314, P92
[2]   THE P75 NERVE GROWTH-FACTOR RECEPTOR MEDIATES SURVIVAL OR DEATH DEPENDING ON THE STAGE OF SENSORY NEURON DEVELOPMENT [J].
BARRETT, GL ;
BARTLETT, PF .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (14) :6501-6505
[3]   ARE REACTIVE OXYGEN SPECIES INVOLVED IN ALZHEIMERS-DISEASE [J].
BENZI, G ;
MORETTI, A .
NEUROBIOLOGY OF AGING, 1995, 16 (04) :661-674
[4]   A new method for staining nerve fibers and nerve endings in mounted paraffin sections [J].
Bodian, D .
ANATOMICAL RECORD, 1936, 65 (01) :89-97
[5]   Decreased TrkA gene expression in cholinergic neurons of the striatum and basal forebrain of patients with Alzheimer's disease [J].
Boissiere, F ;
Faucheux, B ;
Ruberg, M ;
Agid, Y ;
Hirsch, EC .
EXPERIMENTAL NEUROLOGY, 1997, 145 (01) :245-252
[6]   Neurotrophins live or let die: Does p75(NTR) decide? [J].
Carter, BD ;
Lewin, GR .
NEURON, 1997, 18 (02) :187-190
[7]   Selective activation of NF-kappa B by nerve growth factor through the neurotrophin receptor p75 [J].
Carter, BD ;
Kaltschmidt, C ;
Kaltschmidt, B ;
Offenhauser, N ;
BohmMatthaei, R ;
Baeuerle, PA ;
Barde, YA .
SCIENCE, 1996, 272 (5261) :542-545
[8]   Death of oligodendrocytes mediated by the interaction of nerve growth factor with its receptor p75 [J].
CasacciaBonnefil, P ;
Carter, BD ;
Dobrowsky, RT ;
Chao, MV .
NATURE, 1996, 383 (6602) :716-719
[9]   ACTIVATION OF THE SPHINGOMYELIN CYCLE THROUGH THE LOW-AFFINITY NEUROTROPHIN RECEPTOR [J].
DOBROWSKY, RT ;
WERNER, MH ;
CASTELLINO, AM ;
CHAO, MV ;
HANNUN, YA .
SCIENCE, 1994, 265 (5178) :1596-1599
[10]  
Frade JM, 1996, NATURE, V383, P166