Sestamibi scintigraphy, topography, and histopathology of parathyroid glands in secondary hyperparathyroidism

Background. Several imaging techniques presently are available to assess the location of hyperplastic parathyroid glands. The purpose of the present study is to assess the place of dual-phase technetium Tc 99m-sestamibi (MIBI) scintigraphy in the preoperative localization of hyperplastic parathyroid glands in patients with severe secondary hyperparathyroidism (SHPT). Methods We studied 35 consecutive adult white hemodialysis patients undergoing a first parathyroidectomy after performing MIBI scintigraphy. Hyperplasia of the parathyroid glands was classified as diffuse (DH) or nodular (NH). Statistical analysis was conducted by comparing patients with MIBI-negative (no focal area of increased uptake) with MIBI-positive (>= 1 focal area of increased uptake) results and stratifying parathyroid glands according to location (superior and inferior). Results MIBI scintigraphy showed focal areas of increased uptake in at least 1 gland in 25 patients (71.4%). Total number of focal areas of increased uptake was 42 of 121 glands removed (sensitivity, 34.7%; specificity, 100%). One hundred one glands showed NH and 20 glands showed DH. The 25 patients with MIBI-positive results had 85 pathological glands removed, and the 10 patients with MIBI-negative results had 36 pathological glands removed: in the former, most glands showed NH (77 of 85 glands; 90.6%), and in the latter, 24 of 36 glands showed NH (66.7%; P=0.004 at chi-square test). The sensitivity of MIBI scintigraphy for distinguishing specific subtypes of hyperplasia was 37.6%(38 of 101 glands)for NH and 20.0% (4 of 20 glands) for DH (P=0.0005). The following values were significantly greater in inferior compared with superior glands: (1) estimated weight (2.1 +/- 0.8 versus 1.6 +/- 1.2 g; P=0.04), (2) percentage of MIBI positivity(34 of 42 inferior glands [80.9%] versus 8 of 42 superior glands [19.1%]; P=0.0001), and (3) percentage of localization permitted by MIBI scintigraphy (34 of 63 inferior glands [54.0%] versus 8 of 58 superior glands [13.8%]; P=0.0001). Thus, NH, although equally distributed between inferior (53 of 63 glands) and superior (48 of 58 glands) glands, showed a percentage of MIBI positivity significantly greater in inferior (34 of 53 glands [64.1%]) compared with superior glands (8 of 48 glands [16.7%]; P=0.0001). Conclusion: MIBI scintigraphy did not show high sensitivity in identifying hyperplastic glands, although it was able to identify those with NH better than those with DH. Thus, MIBI scintigraphy has limited value preoperatively for patients with SHPT. Estimated weight, percentage of MIBI positivity, and percentage of localization permitted by MIBI scintigraphy were significantly greater in inferior glands.