The state of the STATs: Recent developments in the study of signal transduction to the nucleus

被引：169
作者：
Horvath, CM
Darnell, JE
机构：
[1] Laboratory of Molecular Cell Biology, Rockefeller University, New York, NY 10021
来源：
CURRENT OPINION IN CELL BIOLOGY | 1997年 / 9卷 / 02期
关键词：
D O I：
10.1016/S0955-0674(97)80067-1
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The STATs (signal transducers and activators of transcription) are latent cytoplasmic proteins that, upon activation by cell surface bound polypeptide ligands, move to the nucleus to direct transcription. A variety of protein-protein interactions that affect the function of STATs has been recently recognized. It has become clear that the STATs are functional mosaics, or mixtures of signal transduction and transcription modules.
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收藏
页码：233 / 239
页数：7
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