Depth-resolved imaging of functional activation in the rat cerebral cortex using optical coherence tomography

被引：42

作者：

Aguirre, A. D. ^{[1
]}

Chen, Y.

Fujimoto, J. G.

Ruvinskaya, L.

Devor, A.

Boas, D. A.

机构：

[1] MIT, Dept Elect Engn & Comp Sci, Cambridge, MA 02139 USA

[2] MIT, Elect Res Lab, Cambridge, MA 02139 USA

[3] Massachusetts Gen Hosp, Athinoula A Martinos Ctr, Charlestown, MA 02129 USA

来源：

OPTICS LETTERS | 2006年 / 31卷 / 23期

关键词：

NEURAL ACTIVITY; HEMOGLOBIN CONCENTRATION; SCATTERING CHANGES; BLOOD-FLOW; OXYGENATION;

D O I：

10.1364/OL.31.003459

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

Co-registered optical coherence tomography (OCT) and video microscopy of the rat somatosensory cortex were acquired simultaneously through a thinned skull during forepaw electrical stimulation. Fractional signal change measured by OCT revealed a functional signal time course corresponding to the hemodynamic signal measurement made with video microscopy. OCT can provide high-resolution, cross-sectional images of functional neurovascular activation and may offer a new tool for basic neuroscience research in the important rat cerebral cortex model. (c) 2006 Optical Society of America.

引用

页码：3459 / 3461

页数：3

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