Depth-resolved imaging of functional activation in the rat cerebral cortex using optical coherence tomography

被引:42
作者
Aguirre, A. D. [1 ]
Chen, Y.
Fujimoto, J. G.
Ruvinskaya, L.
Devor, A.
Boas, D. A.
机构
[1] MIT, Dept Elect Engn & Comp Sci, Cambridge, MA 02139 USA
[2] MIT, Elect Res Lab, Cambridge, MA 02139 USA
[3] Massachusetts Gen Hosp, Athinoula A Martinos Ctr, Charlestown, MA 02129 USA
关键词
NEURAL ACTIVITY; HEMOGLOBIN CONCENTRATION; SCATTERING CHANGES; BLOOD-FLOW; OXYGENATION;
D O I
10.1364/OL.31.003459
中图分类号
O43 [光学];
学科分类号
070207 ; 0803 ;
摘要
Co-registered optical coherence tomography (OCT) and video microscopy of the rat somatosensory cortex were acquired simultaneously through a thinned skull during forepaw electrical stimulation. Fractional signal change measured by OCT revealed a functional signal time course corresponding to the hemodynamic signal measurement made with video microscopy. OCT can provide high-resolution, cross-sectional images of functional neurovascular activation and may offer a new tool for basic neuroscience research in the important rat cerebral cortex model. (c) 2006 Optical Society of America.
引用
收藏
页码:3459 / 3461
页数:3
相关论文
共 15 条
[1]   Detection of neural activity using phase-sensitive optical low-coherence reflectometry [J].
Akkin, T ;
Davé, DP ;
Milner, TE ;
Rylander, HG .
OPTICS EXPRESS, 2004, 12 (11) :2377-2386
[2]   Optophysiology: Depth-resolved probing of retinal physiology with functional ultrahigh-resolution optical coherence tomography [J].
Bizheva, K ;
Pflug, R ;
Hermann, B ;
Povazay, B ;
Sattmann, H ;
Qiu, P ;
Anger, E ;
Reitsamer, H ;
Popov, S ;
Taylor, JR ;
Unterhuber, A ;
Ahnelt, P ;
Drexler, W .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (13) :5066-5071
[3]   Ultrahigh resolution real time OCT imaging using a compact femtosecond Nd:Glass laser and nonlinear fiber [J].
Bourquin, S ;
Aguirre, AD ;
Hartl, I ;
Hsiung, P ;
Ko, TH ;
Fujimoto, JG ;
Birks, TA ;
Wadsworth, WJ ;
Bünting, U ;
Kopf, D .
OPTICS EXPRESS, 2003, 11 (24) :3290-3297
[4]   Coupling of total hemoglobin concentration, oxygenation, and neural activity in rat somatosensory cortex [J].
Devor, A ;
Dunn, AK ;
Andermann, ML ;
Ulbert, I ;
Boas, DA ;
Dale, AM .
NEURON, 2003, 39 (02) :353-359
[5]   Simultaneous imaging of total cerebral hemoglobin concentration, oxygenation, and blood flow during functional activation [J].
Dunn, AK ;
Devor, A ;
Bolay, H ;
Andermann, ML ;
Moskowitz, MA ;
Dale, AM ;
Boas, DA .
OPTICS LETTERS, 2003, 28 (01) :28-30
[6]   Noncontact measurement of nerve displacement during action potential with a dual-beam low-coherence interferometer [J].
Fang-Yen, C ;
Chu, MC ;
Seung, HS ;
Dasari, RR ;
Feld, MS .
OPTICS LETTERS, 2004, 29 (17) :2028-2030
[7]   Laminar optical tomography: demonstration of millimeter-scale depth-resolved imaging in turbid media [J].
Hillman, EMC ;
Boas, DA ;
Dale, AM ;
Dunn, AK .
OPTICS LETTERS, 2004, 29 (14) :1650-1652
[8]   OPTICAL COHERENCE TOMOGRAPHY [J].
HUANG, D ;
SWANSON, EA ;
LIN, CP ;
SCHUMAN, JS ;
STINSON, WG ;
CHANG, W ;
HEE, MR ;
FLOTTE, T ;
GREGORY, K ;
PULIAFITO, CA ;
FUJIMOTO, JG .
SCIENCE, 1991, 254 (5035) :1178-1181
[9]   Fluctuations and stimulus-induced changes in blood flow observed in individual capillaries in layers 2 through 4 of rat neocortex [J].
Kleinfeld, D ;
Mitra, PP ;
Helmchen, F ;
Denk, W .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (26) :15741-15746
[10]   Functional optical coherence tomography for detecting neural activity through scattering changes [J].
Lazebnik, M ;
Marks, DL ;
Potgieter, K ;
Gillette, R ;
Boppart, SA .
OPTICS LETTERS, 2003, 28 (14) :1218-1220