Bacillithiol is an antioxidant thiol produced in Bacilli

被引：233

作者：

Newton, Gerald L. ^{[1
]}

Rawat, Mamta ^{[2
]}

La Clair, James J. ^{[1
]}

Jothivasan, Vishnu Karthik ^{[3
]}

Budiarto, Tanya ^{[1
]}

Hamilton, Chris J. ^{[3
]}

Claiborne, Al ^{[4
]}

Helmann, John D. ^{[5
]}

Fahey, Robert C. ^{[1
]}

机构：

[1] Univ Calif San Diego, Dept Chem & Biochem, La Jolla, CA 92093 USA

[2] Calif State Univ Fresno, Dept Biol, Fresno, CA 93740 USA

[3] Univ E Anglia, Sch Chem Sci & Pharm, Norwich NR4 7TJ, Norfolk, England

[4] Wake Forest Univ, Sch Med, Struct Biol Ctr, Winston Salem, NC 27109 USA

[5] Cornell Univ, Dept Microbiol, Ithaca, NY USA

来源：

NATURE CHEMICAL BIOLOGY | 2009年 / 5卷 / 09期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

A-DISULFIDE REDUCTASE; STAPHYLOCOCCUS-AUREUS; SUBTILIS; MYCOTHIOL; BIOSYNTHESIS; PURIFICATION; THIOREDOXIN; EXPRESSION; ANTHRACIS; COMPLEX;

D O I：

10.1038/nchembio.189

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Glutathione is a nearly ubiquitous, low-molecular-mass thiol and antioxidant, but it is conspicuously absent from most Gram-positive bacteria. We identify here the structure of bacillithiol, a newly described and abundant thiol produced by Bacillus species, Staphylococcus aureus and Deinococcus radiodurans. Bacillithiol is the alpha-anomeric glycoside of L-cysteinyl-D-glucosamine with L-malic acid and most probably functions as an antioxidant. Bacillithiol, like the structurally similar mycothiol, may serve as a substitute for glutathione.

引用

页码：625 / 627

页数：3

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