CHEMICAL CONSTITUENTS AND CYTOTOXICITY FROM THE STEM BARK OF CITRUS MEDICA

被引：8

作者：

Chan, Yu-Yi ^{[1
]}

Wu, Tian-Shung ^{[2
]}

Kuo, Yao-Haur ^{[3
]}

机构：

[1] So Taiwan Univ Technol, Dept Biotechnol, Tainan 710, Taiwan

[2] Natl Cheng Kung Univ, Dept Chem, Tainan 701, Taiwan

[3] Natl Res Inst Chinese Med, Taipei 105, Taiwan

来源：

HETEROCYCLES | 2009年 / 78卷 / 05期

关键词：

Citrus medica L. var. sarcodactylis Swingle; Rutaceae; Biscoumarin; Citrumedin-A; OCCURRING HOMOACRIDONE ALKALOIDS; ACRIDONE ALKALOIDS; 1ST EXAMPLES; CITROPONE-B; RING-SYSTEM; PLANTS; COUMARINS; GRANDIS; LIMONOIDS; RUTACEAE;

D O I：

10.3987/COM-08-11630

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new biscoumarin, namely citrumedin-A [6,6',7,7'-tetramethoxy-3,3'-biscoumarin] (1), together with twenty two known compounds were isolated from the stem bark of Citrus medica L. var. sarcodactylis Swingle. The structure of this new compound was completely elucidated using a combination of 2D NMR techniques (COSY, NOESY, HMQC and HMBC) and HR-EI-MS analyses. The known compounds were identified by comparison of their spectroscopic and physical data with those reported in the literatures. The isolates were also screened their cytotoxicity against Daoy, Hep2, MCF-7 and Hela cell lines. Lonchocarpol A (12) showed marginally cytotoxic activity against those four cancer cell lines.

引用

页码：1309 / 1316

页数：8

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