Pullulan in biomedical research and development - A review

被引：95
作者：
Singh, Ram Sarup [1 ]
Kaur, Navpreet [1 ]
Hassan, Muhammad [2 ]
Kennedy, John F. [3 ]
机构：
[1] Punjabi Univ, Dept Biotechnol, Carbohydrate & Prot Biotechnol Lab, Patiala 147002, Punjab, India
[2] Natl Univ Sci & Technol NUST, US Pakistan Ctr Adv Studies Energy, Islamabad 44000, Pakistan
[3] Adv Sci & Technol Inst, Chembiotech Labs, 5 Croft,Buntsford Dr, Bromsgrove B60 4JE, Worcs, England
来源：
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2021年 / 166卷
关键词：
Pullulan; Biomedical industry; Pharmaceutical industry; CHOLESTEROL-BEARING PULLULAN; SELF-ASSEMBLED NANOGELS; COLOR VARIANT STRAIN; IN-VITRO EVALUATION; AUREOBASIDIUM-PULLULANS; GENE DELIVERY; CONTROLLED-RELEASE; ACETATE NANOPARTICLES; DRUG-DELIVERY; ORAL DELIVERY;
D O I：
10.1016/j.ijbiomac.2020.10.227
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Pullulan is an imperative microbial exo-polymer commercially produced by yeast like fungus Aureobasidium pullulans Its structure contains maltosyl repeating units which comprises two alpha-(1 -> 4) linked glucopyranose rings attached to one glucopyranose ring through alpha-(1 -> 6) glycosidic bond. The co-existence of alpha-(1 -> 6) and alpha-(1 -> 4) glycosidic linkages endows distinctive physico-chemical properties to pullulan. It is highly biocompatible, non-toxic and non-carcinogenic in nature. It is extremely resistant to any mutagenicity or immunogenicity. The unique properties of pullulan make it a potent candidate for biomedical applications viz. drug delivery, gene delivery, tissue engineering, molecular chaperon, plasma expander, vaccination. etc. This review highlights the potential of pullulan in biomedical research and development. (C) 2020 Elsevier B.V. All rights reserved.
引用
收藏
页码：694 / 706
页数：13
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