Microwave promoted reaction of purin-6-yl magnesium halides with aldehydes in dichloromethane at 100 °C

被引：6

作者：

Gordon, Malcolm R. ^{[1
]}

Lindell, Stephen D. ^{[1
]}

机构：

[1] Bayer AG, Crop Sci Div, Ind Pk Hochst, Frankfurt, Germany

来源：

TETRAHEDRON LETTERS | 2018年 / 59卷 / 20期

关键词：

Purin-6-yl magnesium halide; Microwave; Dichloromethane; Nucleobase; Grignard; NUCLEOSIDES; PURINES;

D O I：

10.1016/j.tetlet.2018.04.014

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Treatment of a dichloromethane solution of 9-benzyl or 9-phenyl 6-iodopurine with ethereal ethylmagnesium bromide at ambient temperature gives the corresponding purin-6-yl magnesium halides. Addition of an aldehyde followed by heating at 100 degrees C in a microwave reactor yielded the corresponding carbinols in 52-81% yield. (C) 2018 Elsevier Ltd. All rights reserved.

引用

页码：1945 / 1947

页数：3

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