Reduced expression of toll-like receptor 2 on peripheral monocytes in patients with chronic hepatitis B

被引：52
|
作者：
Riordan, Stephen M.
Skinner, Narelle
Kurtovic, Jelica
Locarnini, Stephen
Visvanathan, Kumar
机构：
[1] Prince Wales Hosp, Gastrointestinal & Liver Unit, Randwick, NSW 2031, Australia
[2] Univ New S Wales, Sydney, NSW, Australia
[3] Monash Univ, Dept Infect Dis, Monash Med Ctr, Melbourne, Vic 3004, Australia
[4] Monash Univ, Dept Med, Melbourne, Vic 3004, Australia
[5] Univ Melbourne, Melbourne, Vic, Australia
[6] Victorian Infect Dis Reference Lab, Melbourne, Vic, Australia
来源：
CLINICAL AND VACCINE IMMUNOLOGY | 2006年 / 13卷 / 08期
关键词：
D O I：
10.1128/CVI.00396-05
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Persistent infection with hepatitis B virus (HBV) likely depends on viral inhibition of host defenses. We report that chronic hepatitis B e antigen-positive HBV infection is associated with a significant reduction in peripheral blood monocyte expression of Toll-like receptor 2, a key component of innate immunity, thereby providing a mechanism by which wild-type HBV may establish persistent infection.
引用
收藏
页码：972 / 974
页数：3
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