Recombinant modified vaccinia virus Ankara-based malaria vaccines

被引：27

作者：

Sebastian, Sarah ^{[1
]}

Gilbert, Sarah C. ^{[1
]}

机构：

[1] Univ Oxford, Jenner Inst, Oxford, England

来源：

EXPERT REVIEW OF VACCINES | 2016年 / 15卷 / 01期

关键词：

modified vaccinia virus Ankara (MVA); malaria; plasmodium; vaccine; clinical trials; heterologous prime-boost; PRIME-BOOST IMMUNIZATION; APICAL MEMBRANE ANTIGEN-1; VIRAL-VECTORED VACCINES; LIVER-STAGE ANTIGEN-1; PLASMODIUM-FALCIPARUM INFECTION; T-CELL RESPONSES; CIRCUMSPOROZOITE PROTEIN; PROTECTIVE IMMUNITY; CHIMPANZEE ADENOVIRUS; CANDIDATE VACCINES;

D O I：

10.1586/14760584.2016.1106319

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A safe and effective malaria vaccine is a crucial part of the roadmap to malaria elimination/eradication by the year 2050. Viral-vectored vaccines based on adenoviruses and modified vaccinia virus Ankara (MVA) expressing malaria immunogens are currently being used in heterologous prime-boost regimes in clinical trials for induction of strong antigen-specific T-cell responses and high-titer antibodies. Recombinant MVA is a safe and well-tolerated attenuated vector that has consistently shown significant boosting potential. Advances have been made in large-scale MVA manufacture as high-yield producer cell lines and high-throughput purification processes have recently been developed. This review describes the use of MVA as malaria vaccine vector in both preclinical and clinical studies in the past 5years.

引用

页码：91 / 103

页数：13

共 93 条

[11] A SINGLE FRAGMENT OF A MALARIA MEROZOITE SURFACE PROTEIN REMAINS ON THE PARASITE DURING RED-CELL INVASION AND IS THE TARGET OF INVASION-INHIBITING ANTIBODIES [J].

BLACKMAN, MJ ;

HEIDRICH, HG ;

DONACHIE, S ;

MCBRIDE, JS ;

HOLDER, AA .

JOURNAL OF EXPERIMENTAL MEDICINE, 1990, 172 (01) :379-382

[12]

Bolad A, 2000, SCAND J IMMUNOL, V52, P233

[13] Antigen expression by dendritic cells correlates with the therapeutic effectiveness of a model recombinant poxvirus tumor vaccine [J].

Bronte, V ;

Carroll, MW ;

Goletz, TJ ;

Wang, M ;

Overwijk, WW ;

Marincola, F ;

Rosenberg, SA ;

Moss, B ;

Restifo, NP .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (07) :3183-3188

[14]

Brown Stephen W, 2010, PDA J Pharm Sci Technol, V64, P419

[15] Immune responses against a liver-stage malaria antigen induced by simian adenoviral vector AdCh63 and MVA prime-boost immunisation in non-human primates [J].

Capone, Stefania ;

Reyes-Sandoval, Arturo ;

Naddeo, Mariarosaria ;

Siani, Loredana ;

Ammendola, Virginia ;

Rollier, Christine S. ;

Nicosia, Alfredo ;

Colloca, Stefano ;

Cortese, Riccardo ;

Folgori, Antonella ;

Hill, Adrian V. S. .

VACCINE, 2010, 29 (02) :256-265

[16] The malaria circumsporozoite protein has two functional domains, each with distinct roles as sporozoites journey from mosquito to mammalian host [J].

Coppi, Alida ;

Natarajan, Ramya ;

Pradel, Gabriele ;

Bennett, Brandy L. ;

James, Eric R. ;

Roggero, Mario A. ;

Corradin, Giampietro ;

Persson, Cathrine ;

Tewari, Rita ;

Sinnis, Photini .

JOURNAL OF EXPERIMENTAL MEDICINE, 2011, 208 (02) :341-356

[17] A Phase Ia Study to Assess the Safety and Immunogenicity of New Malaria Vaccine Candidates ChAd63 CS Administered Alone and with MVA CS [J].

de Barra, Eoghan ;

Hodgson, Susanne H. ;

Ewer, Katie J. ;

Bliss, Carly M. ;

Hennigan, Kerrie ;

Collins, Ann ;

Berrie, Eleanor ;

Lawrie, Alison M. ;

Gilbert, Sarah C. ;

Nicosia, Alfredo ;

McConkey, Samuel J. ;

Hill, Adrian V. S. .

PLOS ONE, 2014, 9 (12)

[18] Preclinical assessment of viral vectored and protein vaccines targeting the Duffy-binding protein region II of Plasmodium vivax [J].

de Cassan, Simone C. ;

Shakri, A. Rushdi ;

Llewellyn, David ;

Elias, Sean C. ;

Cho, Jee Sun ;

Goodman, Anna L. ;

Jin, Jing ;

Douglas, Alexander D. ;

Suwanarusk, Rossarin ;

Nosten, Francois H. ;

Renia, Laurent ;

Russell, Bruce ;

Chitnis, Chetan E. ;

Draper, Simon J. .

FRONTIERS IN IMMUNOLOGY, 2015, 6

[19] A PfRH5-Based Vaccine Is Efficacious against Heterologous Strain Blood-Stage Plasmodium falciparum Infection in Aotus Monkeys [J].

Douglas, Alexander D. ;

Baldeviano, G. Christian ;

Lucas, Carmen M. ;

Lugo-Roman, Luis A. ;

Crosnier, Cecile ;

Bartholdson, S. Josefin ;

Diouf, Ababacar ;

Miura, Kazutoyo ;

Lambert, Lynn E. ;

Ventocilla, Julio A. ;

Leiva, Karina P. ;

Milne, Kathryn H. ;

Illingworth, Joseph J. ;

Spencer, Alexandra J. ;

Hjerrild, Kathryn A. ;

Alanine, Daniel G. W. ;

Turner, Alison V. ;

Moorhead, Jeromy T. ;

Edgel, Kimberly A. ;

Wu, Yimin ;

Long, Carole A. ;

Wright, Gavin J. ;

Lescano, Andres G. ;

Draper, Simon J. .

CELL HOST & MICROBE, 2015, 17 (01) :130-139

[20] Tailoring subunit vaccine immunogenicity: Maximizing antibody and T cell responses by using combinations of adenovirus, poxvirus and protein-adjuvant vaccines against Plasmodium falciparum MSP1 [J].

Douglas, Alexander D. ;

de Cassan, Simone C. ;

Dicks, Matthew D. J. ;

Gilbert, Sarah C. ;

Hill, Adrian V. S. ;

Draper, Simon J. .

VACCINE, 2010, 28 (44) :7167-7178

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