Recombinant modified vaccinia virus Ankara-based malaria vaccines

被引：27
作者：
Sebastian, Sarah [1 ]
Gilbert, Sarah C. [1 ]
机构：
[1] Univ Oxford, Jenner Inst, Oxford, England
来源：
EXPERT REVIEW OF VACCINES | 2016年 / 15卷 / 01期
关键词：
modified vaccinia virus Ankara (MVA); malaria; plasmodium; vaccine; clinical trials; heterologous prime-boost; PRIME-BOOST IMMUNIZATION; APICAL MEMBRANE ANTIGEN-1; VIRAL-VECTORED VACCINES; LIVER-STAGE ANTIGEN-1; PLASMODIUM-FALCIPARUM INFECTION; T-CELL RESPONSES; CIRCUMSPOROZOITE PROTEIN; PROTECTIVE IMMUNITY; CHIMPANZEE ADENOVIRUS; CANDIDATE VACCINES;
D O I：
10.1586/14760584.2016.1106319
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
A safe and effective malaria vaccine is a crucial part of the roadmap to malaria elimination/eradication by the year 2050. Viral-vectored vaccines based on adenoviruses and modified vaccinia virus Ankara (MVA) expressing malaria immunogens are currently being used in heterologous prime-boost regimes in clinical trials for induction of strong antigen-specific T-cell responses and high-titer antibodies. Recombinant MVA is a safe and well-tolerated attenuated vector that has consistently shown significant boosting potential. Advances have been made in large-scale MVA manufacture as high-yield producer cell lines and high-throughput purification processes have recently been developed. This review describes the use of MVA as malaria vaccine vector in both preclinical and clinical studies in the past 5years.
引用
收藏
页码：91 / 103
页数：13
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