Enantioselective Synthesis of PPAR (Peroxisome Proliferator-Activated Receptors) Agonists and Antagonists

被引：1
作者：
Goya, Pilar [1 ]
Perez-Fernandez, Ruth [1 ]
Gonzalez-Muniz, Rosario [1 ]
Elguero, Jose [1 ]
机构：
[1] CSIC, Inst Quim Med, E-28006 Madrid, Spain
来源：
CURRENT TOPICS IN MEDICINAL CHEMISTRY | 2014年 / 14卷 / 10期
关键词：
PPAR; enantioselective separation; enantioselective synthesis; Evans' chiral auxiliary; asymmetric hydrogenation; chiral HPLC; chiral salts; PHENYLPROPANOIC ACID-DERIVATIVES; EFFICIENT ASYMMETRIC-SYNTHESIS; ALPHA/GAMMA DUAL AGONISTS; LIGAND-BINDING DOMAIN; BIOLOGICAL EVALUATION; ALPHA AGONIST; DESIGN; POTENCY; AGENTS;
D O I：
10.2174/1568026614666140423112822
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
This review deals with stereoselective issues in PPAR ligands some of which are in clinical use for treating certain metabolic disorders. After a short introduction of these nuclear receptor and their agonists, some cases of enantioselective separations are reported. The main part concerns stereoselective synthesis first starting with asymmetric synthesis from chiral precursors followed by what we refer to as "true" enantioselective methods. Some examples are discussed in detail for each particular heading.
引用
收藏
页码：1283 / 1293
页数：11
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