A functional polyester carrying free hydroxyl groups promotes the mineralization of osteoblast and human mesenchymal stem cell extracellular matrix

被引：44
作者：
Bi, Xiaoping [1 ,2 ,3 ]
You, Zhengwei [2 ,3 ,4 ]
Gao, Jin [2 ,3 ]
Fan, Xianqun [1 ]
Wang, Yadong [2 ,3 ]
机构：
[1] Shanghai Jiao Tong Univ, Sch Med, Shanghai Peoples Hosp 9, Dept Ophthalmol, Shanghai 200011, Peoples R China
[2] Univ Pittsburgh, Dept Bioengn, Pittsburgh, PA 15261 USA
[3] Univ Pittsburgh, McGowan Inst, Pittsburgh, PA 15261 USA
[4] Donghua Univ, Coll Mat Sci & Engn, State Key Lab Modificat Chem Fibers & Polymer Mat, Shanghai 201620, Peoples R China
来源：
ACTA BIOMATERIALIA | 2014年 / 10卷 / 06期
基金：
中国国家自然科学基金;
关键词：
Bone regeneration; Functional polymer; Hydroxyl group; Mineralization; Osteogenesis; TISSUE ENGINEERING APPLICATIONS; RING-OPENING POLYMERIZATION; SELF-ASSEMBLED MONOLAYERS; IMMUNORADIOMETRIC ASSAY; ALKALINE-PHOSPHATASE; SURFACE MODIFICATION; STAINLESS-STEEL; BONE; DIFFERENTIATION; BIOMATERIALS;
D O I：
10.1016/j.actbio.2014.02.018
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
Functional groups can control biointerfaces and provide a simple way to make therapeutic materials. We recently reported the design and synthesis of poly(sebacoyl diglyceride) (PSeD) carrying a free hydroxyl group in its repeating unit. This paper examines the use of this polymer to promote biomineralization for application in bone tissue engineering. PSeD promoted more mineralization of extracellular matrix secreted by human mesenchymal stem cells and rat osteoblasts than poly(lactic-co-glycolic acid) (PLGA), which is currently widely used in bone tissue engineering. PSeD showed in vitro osteocompatibility and in vivo biocompatibility that matched or surpassed that of PLGA, as well as supported the attachment, proliferation and differentiation of rat osteoblasts and human mesenchymal stem cells. This demonstrates the potential of PSeD for use in bone regeneration. (C) 2014 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码：2814 / 2823
页数：10
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