Effects of miR-31 on the osteogenesis of human mesenchymal stem cells

被引：69

作者：

Xie, Qing ^{[1
]}

Wang, Zi ^{[1
]}

Bi, Xiaoping ^{[1
]}

Zhou, Huifang ^{[1
]}

Wang, Yefei ^{[1
]}

Gu, Ping ^{[1
]}

Fan, Xianqun ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Sch Med, Peoples Hosp 9, Dept Ophthalmol, Shanghai 200011, Peoples R China

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2014年 / 446卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Human mesenchymal stem cells (hMSCs); miR-31; SATB2; Osteogenesis; PROGENITOR CELLS; DIFFERENTIATION; BONE; TISSUE; SATB2; RNA;

D O I：

10.1016/j.bbrc.2014.02.058

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Exploring the molecular mechanisms that regulate the osteogenesis of human mesenchymal stem cells (hMSCs) will bring us more efficient methods for improving the treatment of bone-related diseases. In this study, we analyzed the effects of miR-31 on the osteogenesis of hMSCs. The overexpression of miR-31 repressed the osteogenesis of hMSCs, whereas the downregulation enhanced this process. SATB2 was testified to be a direct target of miR-31, and its effects on the osteogenesis were also described. Most importantly, the knockdown of SATB2 attenuated miR-31's osteogenic effects. Taken together, our findings suggest that miR-31 regulates the osteogenesis of hMSCs by targeting SATB2. (C) 2014 Elsevier Inc. All rights reserved.

引用

页码：98 / 104

页数：7

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