Silencing of CDC42 inhibits neuroblastoma cell proliferation and transformation

被引：26

作者：

Lee, Sora ^{[1
]}

Craig, Brian T. ^{[1
]}

Romain, Carmelle V. ^{[1
]}

Qiao, Jingbo ^{[1
]}

Chung, Dai H. ^{[1
,2
]}

机构：

[1] Vanderbilt Univ, Dept Pediat Surg, Med Ctr, Nashville, TN 37232 USA

[2] Vanderbilt Univ, Dept Canc Biol, Med Ctr, Nashville, TN 37232 USA

来源：

CANCER LETTERS | 2014年 / 355卷 / 02期

基金：

美国国家卫生研究院;

关键词：

CDC42; AKT2; Twist; N-myc; Transformation; Neuroblastoma; CANCER-CELLS; N-MYC; COLORECTAL-CANCER; TUMOR-METASTASIS; UP-REGULATION; RHO-GTPASES; TWIST; INVASION; DIFFERENTIATION; MORPHOGENESIS;

D O I：

10.1016/j.canlet.2014.08.033

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cell division cycle 42 (CDC42), a small GTPase of the Rho-subfamily, regulates diverse cellular functions including proliferation, cytoskeletal rearrangement and even promotes malignant transformation. Here, we found that increased expression of CDC42 correlated with undifferentiated neuroblastoma as compared to a more benign phenotype. CDC42 inhibition decreased cell growth and soft agar colony formation, and increased cell death in BE(2)-C and BE(2)-M17 cell lines, but not in SK-N-AS. In addition, silencing of CDC42 decreased expression of N-myc in BE(2)-C and BE(2)-M17 cells. Our findings suggest that CDC42 may play a role in the regulation of aggressive neuroblastoma behavior. (C) 2014 Elsevier Ireland Ltd. All rights reserved.

引用

页码：210 / 216

页数：7

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