Parenting from before conception

被引：227
作者：
Lane, Michelle
Robker, Rebecca L.
Robertson, Sarah A. [1 ]
机构：
[1] Univ Adelaide, Robinson Res Inst, Sch Med, South Adelaide, SA 5005, Australia
来源：
SCIENCE | 2014年 / 345卷 / 6198期
基金：
英国医学研究理事会;
关键词：
IN-VITRO FERTILIZATION; HIGH-FAT DIET; TRANSGENERATIONAL EPIGENETIC INHERITANCE; FEMALE REPRODUCTIVE-TRACT; DEVELOPMENTAL ORIGINS; GENE-EXPRESSION; TRANSCRIPTIONAL PROFILE; VASCULAR DYSFUNCTION; MATERNAL NUTRITION; PATERNAL OBESITY;
D O I：
10.1126/science.1254400
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
At fertilization, the gametes endow the embryo with a genomic blueprint, the integrity of which is affected by the age and environmental exposures of both parents. Recent studies reveal that parental history and experiences also exert effects through epigenomic information not contained in the DNA sequence, including variations in sperm and oocyte cytosine methylation and chromatin patterning, noncoding RNAs, and mitochondria. Transgenerational epigenetic effects interact with conditions at conception to program the developmental trajectory of the embryo and fetus, ultimately affecting the lifetime health of the child. These insights compel us to revise generally held notions to accommodate the prospect that biological parenting commences well before birth, even prior to conception.
引用
收藏
页码：756 / 760
页数：5
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