Circulating osteocalcin as a bone-derived hormone is inversely correlated with body fat in patients with type 1 diabetes

被引：12

作者：

Takashi, Yuichi ^{[1
]}

Ishizu, Masashi ^{[1
,2
]}

Mori, Hiroyasu ^{[1
]}

Miyashita, Kazuyuki ^{[3
]}

Sakamoto, Fumie ^{[3
]}

Katakami, Naoto ^{[3
]}

Matsuoka, Taka-aki ^{[3
]}

Yasuda, Tetsuyuki ^{[4
]}

Hashida, Seiichi ^{[5
]}

Matsuhisa, Munehide ^{[1
]}

Kuroda, Akio ^{[1
]}

机构：

[1] Tokushima Univ, Inst Adv Med Sci, Diabet Therapeut & Res Ctr, Tokushima, Japan

[2] Tokushima Univ, Grad Sch Biomed Sci, Dept Hematol Endocrinol & Metab, Tokushima, Japan

[3] Osaka Univ, Grad Sch Med, Dept Metab Med, Osaka, Japan

[4] Osaka Police Hosp, Dept Diabet & Endocrinol, Osaka, Japan

[5] Tokushima Bunri Univ, Inst Hlth Sci, Tokushima, Japan

来源：

PLOS ONE | 2019年 / 14卷 / 05期

关键词：

SERUM UNDERCARBOXYLATED OSTEOCALCIN; BETA-CELL; GLUCOSE-HOMEOSTASIS; RISK; MASS; TURNOVER; MARKERS; ADULTS;

D O I：

10.1371/journal.pone.0216416

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The objective of the present study was to investigate the correlations between serum under-carboxylated osteocalcin (ucOC) or osteocalcin (OC) concentrations and %body fat, serum adiponectin and free-testosterone concentration, muscle strength and dose of exogenous insulin in patients with type 1 diabetes. We recruited 73 Japanese young adult patients with childhood-onset type 1 diabetes. All participants were receiving insulin replacement therapy. The correlations between logarithmic serum ucOC or OC concentrations and each parameter were examined. Serum ucOC and OC concentrations were inversely correlated with% body fat (r = -0.319, P = 0.007; r = -0.321, P = 0.006, respectively). Furthermore, multiple linear regression analyses were performed to determine whether or not serum ucOC or OC concentrations were factors associated with % body fat. Serum ucOC and OC concentrations remained significant factors even after adjusting for gender, HbA1c, body weight-adjusted total daily dose of insulin and duration of diabetes (beta = -0.260, P = 0.027; beta = -0.254, P = 0.031, respectively). However, serum ucOC and OC concentrations were not correlated with serum adiponectin or free-testosterone concentrations, muscle strength or dose of exogenous insulin. In conclusion, our study demonstrates the inverse correlation between serum ucOC or OC concentrations and body fat in patients with type 1 diabetes.

引用

页数：11

共 36 条

[1] Utility of multifrequency bioelectrical impedance compared with dual-energy x-ray absorptiometry for assessment of total and regional body composition varies between men and women [J].