Hampering Immune Suppressors Therapeutic Targeting of Myeloid-Derived Suppressor Cells in Cancer

被引：49

作者：

Albeituni, Sabrin Husein ^{[1
]}

Ding, Chuanlin ^{[2
]}

Yan, Jun ^{[1
,2
]}

机构：

[1] Univ Louisville, Dept Microbiol & Immunol, Louisville, KY 40202 USA

[2] Univ Louisville, Div Hematol & Med Oncol, Dept Med, James Graham Brown Canc Ctr, Louisville, KY 40202 USA

来源：

CANCER JOURNAL | 2013年 / 19卷 / 06期

关键词：

MDSC; differentiation; immune suppression; therapeutic targeting; COLONY-STIMULATING FACTOR; TUMOR-BEARING MICE; T-CELL; BONE-MARROW; 1-ALPHA; 25-DIHYDROXYVITAMIN D-3; ANTITUMOR IMMUNITY; KINASE INHIBITOR; DENDRITIC CELLS; PROTEIN-KINASE; NITRIC-OXIDE;

D O I：

10.1097/PPO.0000000000000006

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of immature myeloid cells with suppressive properties that preferentially expand in cancer. Myeloid-derived suppressor cells mainly suppress T-cell proliferation and cytotoxicity, inhibit natural killer cell activation, and induce the differentiation and expansion of regulatory T cells. The wide spectrum of MDSC suppressive activity in cancer and its role in tumor progression have rendered these cells a promising target for effective cancer immunotherapy. In this review we briefly discuss the origin of MDSCs and their main mechanisms of suppression and focus more on the approaches developed up to date targeting of MDSCs in tumor-bearing animals and cancer patients.

引用

页码：490 / 501

页数：12

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