Biodegradable, pH-Responsive Carboxymethyl Cellulose/Poly(Acrylic Acid) Hydrogels for Oral Insulin Delivery

被引：126
作者：
Gao, Xiaoye [1 ]
Cao, Yue [1 ]
Song, Xiangfu [2 ]
Zhang, Zhe [1 ,3 ]
Zhuang, Xiuli [1 ]
He, Chaoliang [1 ]
Chen, Xuesi [1 ]
机构：
[1] Chinese Acad Sci, Changchun Inst Appl Chem, Key Lab Polymer Ecomat, Changchun 130022, Peoples R China
[2] Jilin Univ, Sch Publ Hlth, Changchun 130021, Peoples R China
[3] NE Normal Univ, Dept Chem, Changchun 130022, Peoples R China
来源：
MACROMOLECULAR BIOSCIENCE | 2014年 / 14卷 / 04期
基金：
中国国家自然科学基金;
关键词：
biodegradable hydrogels; controlled release; oral delivery; pH-responsive; COMPLEXATION HYDROGELS; ENZYMATIC DEGRADATION; SENSITIVE HYDROGEL; DRUG-DELIVERY; CELLULOSE; CHITOSAN; NETWORK; GROWTH; MICROPARTICLES; NANOPARTICLES;
D O I：
10.1002/mabi.201300384
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Biodegradable and pH-responsive carboxymethyl cellulose/poly(acrylic acid) hybrid hydrogels are synthesized. The hydrogels deswell in acidic artificial gastric fluid (AGF) but rapidly swell in neutral artificial intestinal fluid (AIF), rendering selective enzymatic degradation of the gels as well as accelerated drug release from insulin-loaded hydrogels in AIF. Oral administration of insulin-loaded hydrogels to streptozotocin-induced diabetic rats leads to a continuous decline in the fasting blood glucose level within 6h post-administration, and the relative pharmacological availability increases more than 10 times compared to oral administration of free insulin solution. The relative bioavailability of hydrogel-encapsulated insulin after oral administration to healthy rabbits is 6.6%.
引用
收藏
页码：565 / 575
页数：11
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