Can helminths or helminth-derived products be used in humans to prevent or treat allergic diseases?

被引：61

作者：

Erb, Klaus J. ^{[1
]}

机构：

[1] Boehringer Ingelheim Pharma GmbH & Co KG, Dept Pulm Res, D-88440 Biberach Ad Riss, Germany

来源：

TRENDS IN IMMUNOLOGY | 2009年 / 30卷 / 02期

关键词：

REGULATORY T-CELLS; SCHISTOSOMA-MANSONI INFECTION; INDUCED AIRWAY HYPERRESPONSIVENESS; TRICHURIS-SUIS INFECTION; SCHOOL-CHILDREN; INFLAMMATORY RESPONSES; ANTHELMINTIC TREATMENT; NEGATIVE ASSOCIATION; IMMUNE-RESPONSES; ATOPIC DISORDERS;

D O I：

10.1016/j.it.2008.11.005

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Recent epidemiological and experimental data indicate that infection with helminths can protect humans from the development of allergic disorders by immunosuppressive mechanisms that involve the induction of IL-10 and/or regulatory T cells. Furthermore, helminth-derived immune modulators suppress allergic responses in mice. Trichuris suis therapy has been shown to be safe and efficacious in treating inflammatory bowel disease in humans. Has the time come to treat patients who have allergic diseases or healthy humans who are at risk of developing these diseases with helminths or helminth-derived products? Here, I discuss the pros and cons of such an approach.

引用

页码：75 / 82

页数：8

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