In this work, we considered the autoantibodies proposed as putative biomarkers of demyelination taking into account their reactivity towards myelin oligodendrocyte glycoprotein (MOG) and myelin basic protein (MBP). These myelin proteins are among the most commonly researched targets in the immunopathology of demyelinating diseases. In this context, the development of assays for autoantibody detection can contribute as a predictive value for the early diagnosis of demyelinating diseases. Hence, we aimed to address the application of silver nanoparticles (AgNPs) as a sensing device of autoantibodies. AgNPs were synthesized via a chemical reduction method and characterized using atomic force microscopy (AFM), X-ray diffractometry, dynamic light scattering, and UV-visible spectrophotometry. The process of peptide conjugation on the nanoparticles was also analyzed. The autoantibody recognition by the peptide-conjugated AgNPs was evaluated with UV-visible spectrophotometry, atomic force spectroscopy (AFS), and color changing. AgNPs exhibited spherical morphology, low polydispersity, face-centered cubic crystal structure, and an average size of 29.3 +/- 3.0 nm. The hydrodynamic diameter variation and AFM showed that the MBP peptide induced greater agglomeration, compared to MOG peptide. The AFS measurements indicated the efficient binding of peptides to the AgNPs maintaining their activity, revealed by typical adhesion force and shapes of curves. The absorption spectrum features were more affected by the interaction with the specific autoantibodies, which also caused a visible color change in suspension providing a qualitative response. We described a preliminary study of MOG- and MBP-conjugated AgNPs which showed to be applicable in the autoantibody recognition. These have promising implication in the searching for biological markers for diagnostic purposes in the demyelination context, in which the nanoscale sensing exploitation is recent.
机构:
Hong Kong Baptist Univ, Sch Chinese Med, Hong Kong 999077, Peoples R ChinaHong Kong Baptist Univ, Sch Chinese Med, Hong Kong 999077, Peoples R China
Gaurav, Isha
Thakur, Abhimanyu
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h-index: 0
机构:
Delhi Pharmaceut Sci & Res Univ DPSRU, Dept Pharmacol, New Delhi 110017, India
Harvard Med Sch, Massachusetts Gen Hosp, Dept Neurosurg, Boston, MA 02115 USAHong Kong Baptist Univ, Sch Chinese Med, Hong Kong 999077, Peoples R China
Thakur, Abhimanyu
Zhang, Kui
论文数: 0引用数: 0
h-index: 0
机构:
Univ Chicago, Pritzker Sch Mol Engn, Ben May Dept Canc Res, Chicago, IL 60637 USAHong Kong Baptist Univ, Sch Chinese Med, Hong Kong 999077, Peoples R China
Zhang, Kui
Thakur, Sudha
论文数: 0引用数: 0
h-index: 0
机构:
Natl Inst Locomotor Disabil Divyangjan, Kolkata 700090, IndiaHong Kong Baptist Univ, Sch Chinese Med, Hong Kong 999077, Peoples R China
Thakur, Sudha
Hu, Xin
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h-index: 0
机构:
Southwest Univ, Med Res Inst, State Key Lab Resource Insects, Chongqing 400715, Peoples R ChinaHong Kong Baptist Univ, Sch Chinese Med, Hong Kong 999077, Peoples R China
Hu, Xin
Xu, Zhijie
论文数: 0引用数: 0
h-index: 0
机构:
Cent South Univ, Xiangya Hosp, Dept Pathol, Changsha 410017, Peoples R China
Cent South Univ, Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Changsha 410017, Peoples R ChinaHong Kong Baptist Univ, Sch Chinese Med, Hong Kong 999077, Peoples R China
Xu, Zhijie
Kumar, Gaurav
论文数: 0引用数: 0
h-index: 0
机构:
Galgotias Univ, Sch Basic & Appl Sci, Dept Biosci, Clin Res Div,Dept Biosci, Greater Noida 203201, IndiaHong Kong Baptist Univ, Sch Chinese Med, Hong Kong 999077, Peoples R China
Kumar, Gaurav
Jaganathan, Ravindran
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h-index: 0
机构:
Univ Kuala Lumpur, Royal Coll Med Perak UniKL RCMP, Preclin Dept, Ipoh 30450, MalaysiaHong Kong Baptist Univ, Sch Chinese Med, Hong Kong 999077, Peoples R China
Jaganathan, Ravindran
Iyaswamy, Ashok
论文数: 0引用数: 0
h-index: 0
机构:
Hong Kong Baptist Univ, Sch Chinese Med, Hong Kong 999077, Peoples R China
Hong Kong Baptist Univ, Mr & Mrs Ko Chi Ming Ctr Parkinsons Dis Res, Sch Chinese Med, Hong Kong 999077, Peoples R China
Karpagam Acad Higher Educ, Dept Biochem, Coimbatore 641021, IndiaHong Kong Baptist Univ, Sch Chinese Med, Hong Kong 999077, Peoples R China
Iyaswamy, Ashok
Li, Min
论文数: 0引用数: 0
h-index: 0
机构:
Hong Kong Baptist Univ, Sch Chinese Med, Hong Kong 999077, Peoples R China
Hong Kong Baptist Univ, Mr & Mrs Ko Chi Ming Ctr Parkinsons Dis Res, Sch Chinese Med, Hong Kong 999077, Peoples R ChinaHong Kong Baptist Univ, Sch Chinese Med, Hong Kong 999077, Peoples R China
Li, Min
Zhang, Ge
论文数: 0引用数: 0
h-index: 0
机构:
Hong Kong Baptist Univ, Law Sau Fai Inst Adv Translat Med Bone & Joint Dis, Sch Chinese Med, Hong Kong 999077, Peoples R China
Hong Kong Baptist Univ, Inst Integrated Bioinfomedicine & Translat Sci, Sch Chinese Med, Hong Kong 999077, Peoples R China
HKBU Inst Res & Continuing Educ, Inst Precis Med & Innovat Drug Discovery, Shenzhen 518000, Peoples R ChinaHong Kong Baptist Univ, Sch Chinese Med, Hong Kong 999077, Peoples R China
Zhang, Ge
Yang, Zhijun
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h-index: 0
机构:
Hong Kong Baptist Univ, Sch Chinese Med, Hong Kong 999077, Peoples R ChinaHong Kong Baptist Univ, Sch Chinese Med, Hong Kong 999077, Peoples R China
机构:
Natl Taiwan Normal Univ, Dept Chem, Taipei 116, TaiwanAcad Sinica, Genom Res Ctr, Taipei 115, Taiwan
Wang, Di-Yan
Teng, Tzu-Shen
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Acad Sinica, Genom Res Ctr, Taipei 115, Taiwan
Natl Taiwan Normal Univ, Dept Chem, Taipei 116, TaiwanAcad Sinica, Genom Res Ctr, Taipei 115, Taiwan
Teng, Tzu-Shen
Wu, Yi-Chou
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Natl Taiwan Normal Univ, Dept Chem, Taipei 116, TaiwanAcad Sinica, Genom Res Ctr, Taipei 115, Taiwan
Wu, Yi-Chou
Lee, Yi-Cheng
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Acad Sinica, Genom Res Ctr, Taipei 115, TaiwanAcad Sinica, Genom Res Ctr, Taipei 115, Taiwan
Lee, Yi-Cheng
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机构:
Chen, Kuei-Hsien
Chen, Chung-Hsuan
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Acad Sinica, Genom Res Ctr, Taipei 115, TaiwanAcad Sinica, Genom Res Ctr, Taipei 115, Taiwan
Chen, Chung-Hsuan
Chang, Ying-Chih
论文数: 0引用数: 0
h-index: 0
机构:
Acad Sinica, Genom Res Ctr, Taipei 115, TaiwanAcad Sinica, Genom Res Ctr, Taipei 115, Taiwan
Chang, Ying-Chih
Chen, Chia-Chun
论文数: 0引用数: 0
h-index: 0
机构:
Natl Taiwan Normal Univ, Dept Chem, Taipei 116, Taiwan
Acad Sinica, Inst Atom & Mol Sci, Taipei 106, TaiwanAcad Sinica, Genom Res Ctr, Taipei 115, Taiwan
机构:
Hong Kong Baptist Univ, Sch Chinese Med, Hong Kong 999077, Peoples R ChinaHong Kong Baptist Univ, Sch Chinese Med, Hong Kong 999077, Peoples R China
Gaurav, Isha
Thakur, Abhimanyu
论文数: 0引用数: 0
h-index: 0
机构:
Delhi Pharmaceut Sci & Res Univ DPSRU, Dept Pharmacol, New Delhi 110017, India
Harvard Med Sch, Massachusetts Gen Hosp, Dept Neurosurg, Boston, MA 02115 USAHong Kong Baptist Univ, Sch Chinese Med, Hong Kong 999077, Peoples R China
Thakur, Abhimanyu
Zhang, Kui
论文数: 0引用数: 0
h-index: 0
机构:
Univ Chicago, Pritzker Sch Mol Engn, Ben May Dept Canc Res, Chicago, IL 60637 USAHong Kong Baptist Univ, Sch Chinese Med, Hong Kong 999077, Peoples R China
Zhang, Kui
Thakur, Sudha
论文数: 0引用数: 0
h-index: 0
机构:
Natl Inst Locomotor Disabil Divyangjan, Kolkata 700090, IndiaHong Kong Baptist Univ, Sch Chinese Med, Hong Kong 999077, Peoples R China
Thakur, Sudha
Hu, Xin
论文数: 0引用数: 0
h-index: 0
机构:
Southwest Univ, Med Res Inst, State Key Lab Resource Insects, Chongqing 400715, Peoples R ChinaHong Kong Baptist Univ, Sch Chinese Med, Hong Kong 999077, Peoples R China
Hu, Xin
Xu, Zhijie
论文数: 0引用数: 0
h-index: 0
机构:
Cent South Univ, Xiangya Hosp, Dept Pathol, Changsha 410017, Peoples R China
Cent South Univ, Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Changsha 410017, Peoples R ChinaHong Kong Baptist Univ, Sch Chinese Med, Hong Kong 999077, Peoples R China
Xu, Zhijie
Kumar, Gaurav
论文数: 0引用数: 0
h-index: 0
机构:
Galgotias Univ, Sch Basic & Appl Sci, Dept Biosci, Clin Res Div,Dept Biosci, Greater Noida 203201, IndiaHong Kong Baptist Univ, Sch Chinese Med, Hong Kong 999077, Peoples R China
Kumar, Gaurav
Jaganathan, Ravindran
论文数: 0引用数: 0
h-index: 0
机构:
Univ Kuala Lumpur, Royal Coll Med Perak UniKL RCMP, Preclin Dept, Ipoh 30450, MalaysiaHong Kong Baptist Univ, Sch Chinese Med, Hong Kong 999077, Peoples R China
Jaganathan, Ravindran
Iyaswamy, Ashok
论文数: 0引用数: 0
h-index: 0
机构:
Hong Kong Baptist Univ, Sch Chinese Med, Hong Kong 999077, Peoples R China
Hong Kong Baptist Univ, Mr & Mrs Ko Chi Ming Ctr Parkinsons Dis Res, Sch Chinese Med, Hong Kong 999077, Peoples R China
Karpagam Acad Higher Educ, Dept Biochem, Coimbatore 641021, IndiaHong Kong Baptist Univ, Sch Chinese Med, Hong Kong 999077, Peoples R China
Iyaswamy, Ashok
Li, Min
论文数: 0引用数: 0
h-index: 0
机构:
Hong Kong Baptist Univ, Sch Chinese Med, Hong Kong 999077, Peoples R China
Hong Kong Baptist Univ, Mr & Mrs Ko Chi Ming Ctr Parkinsons Dis Res, Sch Chinese Med, Hong Kong 999077, Peoples R ChinaHong Kong Baptist Univ, Sch Chinese Med, Hong Kong 999077, Peoples R China
Li, Min
Zhang, Ge
论文数: 0引用数: 0
h-index: 0
机构:
Hong Kong Baptist Univ, Law Sau Fai Inst Adv Translat Med Bone & Joint Dis, Sch Chinese Med, Hong Kong 999077, Peoples R China
Hong Kong Baptist Univ, Inst Integrated Bioinfomedicine & Translat Sci, Sch Chinese Med, Hong Kong 999077, Peoples R China
HKBU Inst Res & Continuing Educ, Inst Precis Med & Innovat Drug Discovery, Shenzhen 518000, Peoples R ChinaHong Kong Baptist Univ, Sch Chinese Med, Hong Kong 999077, Peoples R China
Zhang, Ge
Yang, Zhijun
论文数: 0引用数: 0
h-index: 0
机构:
Hong Kong Baptist Univ, Sch Chinese Med, Hong Kong 999077, Peoples R ChinaHong Kong Baptist Univ, Sch Chinese Med, Hong Kong 999077, Peoples R China
机构:
Natl Taiwan Normal Univ, Dept Chem, Taipei 116, TaiwanAcad Sinica, Genom Res Ctr, Taipei 115, Taiwan
Wang, Di-Yan
Teng, Tzu-Shen
论文数: 0引用数: 0
h-index: 0
机构:
Acad Sinica, Genom Res Ctr, Taipei 115, Taiwan
Natl Taiwan Normal Univ, Dept Chem, Taipei 116, TaiwanAcad Sinica, Genom Res Ctr, Taipei 115, Taiwan
Teng, Tzu-Shen
Wu, Yi-Chou
论文数: 0引用数: 0
h-index: 0
机构:
Natl Taiwan Normal Univ, Dept Chem, Taipei 116, TaiwanAcad Sinica, Genom Res Ctr, Taipei 115, Taiwan
Wu, Yi-Chou
Lee, Yi-Cheng
论文数: 0引用数: 0
h-index: 0
机构:
Acad Sinica, Genom Res Ctr, Taipei 115, TaiwanAcad Sinica, Genom Res Ctr, Taipei 115, Taiwan
Lee, Yi-Cheng
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机构:
Chen, Kuei-Hsien
Chen, Chung-Hsuan
论文数: 0引用数: 0
h-index: 0
机构:
Acad Sinica, Genom Res Ctr, Taipei 115, TaiwanAcad Sinica, Genom Res Ctr, Taipei 115, Taiwan
Chen, Chung-Hsuan
Chang, Ying-Chih
论文数: 0引用数: 0
h-index: 0
机构:
Acad Sinica, Genom Res Ctr, Taipei 115, TaiwanAcad Sinica, Genom Res Ctr, Taipei 115, Taiwan
Chang, Ying-Chih
Chen, Chia-Chun
论文数: 0引用数: 0
h-index: 0
机构:
Natl Taiwan Normal Univ, Dept Chem, Taipei 116, Taiwan
Acad Sinica, Inst Atom & Mol Sci, Taipei 106, TaiwanAcad Sinica, Genom Res Ctr, Taipei 115, Taiwan