Functionalized imidazolium salt: an efficient catalyst for Buchwald-Hartwig type C-N cross-coupling of (hetero)aryl chlorides/bromides with amines under solvent-, inert gas-, and base-free ambience

The intermingling of novel imidazolium salt (HL1-Br) and Cu(OAc)(2) has been marked down as a highly efficient catalytic system for Buchwald-Hartwig-type C-N coupling of a variety of amines with (hetero) aryl bromides/chlorides. In contrast to the whole realm of C-N coupling, the developed protocol is facilitated under base-, solvent-, and inert-gas-free conditions. The established NHC-based imidazolium salt 3-(2-(2-methoxyphenyl)-2-oxoethyl)-1-(pyridin-2-yl)-1H-imidazo-3-ium bromide (HL1-Br) along with Cu cooperate to undergo various types of diversification. This broadens the range of C-N coupling in numerous applications and gives rise to innovative solutions for challenges in catalytic, synthetic chemistry and drug discovery. The developed reaction proceeds at 110 degrees C and produces a broad spectrum of substrates in good to excellent yields.