Chromoblastomycosis Caused by Phialophora-Proven Cases from Mexico

被引：7
作者：
Ahmed, Sarah A. [1 ,2 ,3 ]
Bonifaz, Alexandro [4 ]
Gonzalez, Gloria M. [5 ]
Moreno, Leandro F. [6 ]
Menezes da Silva, Nickolas [1 ,7 ,8 ]
Vicente, Vania A. [7 ]
Li, Ruoyu [9 ]
de Hoog, Sybren [1 ,3 ,7 ]
机构：
[1] Radboud Univ Nijmegen, Canisius Wilhelmina Hosp, Med Ctr, Ctr Expertise Mycol, NL-6525 GA Nijmegen, Netherlands
[2] Univ Khartoum, Fac Med Lab Sci, Khartoum 11115, Sudan
[3] Fdn Atlas Clin Fungi, NL-1214 GP Hilversum, Netherlands
[4] Hosp Gen Mexico Dr Eduardo Liceaga, Dr Balmis 148, Ciudad De Mexico 06720, Mexico
[5] Univ Autonoma Nuevo Leon, Sch Med, Microbiol Dept, Monterrey 64460, Mexico
[6] Amsterdam Med Ctr, NL-1105 AZ Amsterdam, Netherlands
[7] Univ Fed Parana, Dept Basic Pathol, BR-81530000 Curitiba, Parana, Brazil
[8] Univ Fed Parana, Grad Program Bioproc Engn & Biotechnol, BR-81530000 Curitiba, Parana, Brazil
[9] Peking Univ, Peking Univ First Hosp, Res Ctr Med Mycol, Dept Dermatol, Beijing 100034, Peoples R China
来源：
JOURNAL OF FUNGI | 2021年 / 7卷 / 02期
关键词：
chromoblastomycosis; genome; Mexico; molecular identification; Phialophora americana; Phialophora chinensis; Phialophora macrospora; Phialophora verrucosa; BLACK YEASTS; VERRUCOSA; RELATIVES; DISEASE;
D O I：
10.3390/jof7020095
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Chromoblastomycosis is a chronic severely mutilating disease caused by fungi of the order Chaetothyriales. Classically, Phialophora verrucosa has been listed among these etiologic agents. This species is known to occur in the environment and has been found to cause other infections like phaeohyphomycosis, while reported cases of chromoblastomycosis are scant. Phialophora is phylogenetically diverse, and thus retrospective confirmation of etiology is necessary. We studied ten proven cases of chromoblastomycosis from Mexico and further analyzed the population genetics and genomics of the Phialophora species to understand their pathogenicity and predilection. The clinical strains were molecularly identified as Phialophora americana (n = 4), Phialophora chinensis (n = 4), and Phialophora macrospora (n = 2). No genetic distinction between clinical and environmental strains was possible. Further analysis of strains from diverse origins are needed to address eventual differences in virulence and niche predilection between the species.
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页码：1 / 14
页数：14
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