Should concomitant and adjuvant treatment with temozolomide be used as standard therapy in patients with anaplastic glioma?

被引：28

作者：

Siker, Malika L.

Chakravarti, Arnab

Mehta, Minesh P.

机构：

[1] Univ Wisconsin, Sch Med & Publ Hlth, Dept Human Oncol, Madison, WI 53792 USA

[2] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Dept Radiat Oncol, Boston, MA 02115 USA

来源：

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY | 2006年 / 60卷 / 02期

关键词：

anaplastic glioma; astrocytoma; oligodendroglioma; oligoastrocytoma; temozolomide; radiotherapy; chemotherapy; chemoradiotherapy;

D O I：

10.1016/j.critrevonc.2006.04.005

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Malignant gliomas are devastating tumors associated with poor prognosis. Standard treatment has been surgery followed by radiotherapy while the role of chemotherapy has remained controversial. Concomitant and adjuvant treatment with temozolomide has recently been shown to improve survival in patients with glioblastoma. While it seems intuitive to apply this regimen to patients with anaplastic gliomas which have traditionally been considered more chemosensitive, chemotherapy has not been shown to prolong life in patients with anaplastic gliomas. Despite promising preclinical and early clinical results, there is currently not enough level I evidence to justify concomitant and adjuvant temozolomide as standard therapy for patients with newly diagnosed anaplastic gliomas. Further investigation is needed to better define the role of chemotherapy in patients with anaplastic gliomas. Trials evaluating chemoradiotherapy as well as targeted therapeutic agents are the subject of further research. (c) 2006 Elsevier Ireland Ltd. All rights reserved.

引用

页码：99 / 111

页数：13

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