Biophysical model of AMPA receptor trafficking and its regulation during long-term potentiation/long-term depression

被引:62
作者
Earnshaw, Berton A. [1 ]
Bressloff, Paul C. [1 ]
机构
[1] Univ Utah, Dept Math, Salt Lake City, UT 84112 USA
关键词
AMPA receptor trafficking; long-term potentiation; long-term depression; synaptic plasticity; exocytosis/endocytosis; membrane diffusion; BIDIRECTIONAL SYNAPTIC PLASTICITY; GLUTAMATE RECEPTORS; SUBUNIT GLUR2; TIME-COURSE; PHOSPHORYLATION; TRANSMISSION; DIFFUSION; SYNAPSES; ORGANIZATION; ENDOCYTOSIS;
D O I
10.1523/JNEUROSCI.3601-06.2006
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
AMPA receptors mediate the majority of fast excitatory synaptic transmission in the CNS, and evidence suggests that AMPA receptor trafficking regulates synaptic strength, a phenomenon implicated in learning and memory. There are two major mechanisms of AMPA receptor trafficking: exocytic/endocytic exchange of surface receptors with intracellular receptor pools, and the lateral diffusion or hopping of surface receptors between the postsynaptic density and the surrounding extrasynaptic membrane. In this paper, we present a biophysical model of these trafficking mechanisms under basal conditions and during the expression of long-term potentiation (LTP) and depression (LTD). We show how our model reproduces a wide range of physiological data, and use this to make predictions regarding possible targets of second-messenger pathways activated during the induction phase of LTP/LTD.
引用
收藏
页码:12362 / 12373
页数:12
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