More than an anticoagulant: Do heparins have direct anti-inflammatory effects?

被引：152

作者：

Poterucha, Timothy J. ^{[1
]}

Libby, Peter ^{[2
]}

Goldhaber, Samuel Z. ^{[2
]}

机构：

[1] Harvard Med Sch, Brigham & Womens Hosp, Dept Med, Boston, MA USA

[2] Harvard Med Sch, Brigham & Womens Hosp, Div Cardiovasc Med, Dept Med, Boston, MA USA

来源：

THROMBOSIS AND HAEMOSTASIS | 2017年 / 117卷 / 03期

基金：

美国国家卫生研究院;

关键词：

Heparin; coagulation; inflammation; LOW-MOLECULAR-WEIGHT; NEUTROPHIL EXTRACELLULAR TRAPS; SMOOTH-MUSCLE-CELLS; TISSUE FACTOR; P-SELECTIN; KAPPA-B; VENOUS THROMBOEMBOLISM; INFLAMMATORY DISEASES; ENDOTHELIAL-CELLS; CANCER-PATIENTS;

D O I：

10.1160/TH16-08-0620

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The heparins, well-known for their anticoagulant properties, may also have anti-inflammatory effects that could contribute to their effectiveness in the treatment of venous thromboembolism and other vascular diseases. This review focuses on the inflammatory pathophysiology that underlies the development of thrombosis and the putative effects of heparin on these pathways. We present evidence supporting the use of heparin for other indications, including autoimmune disease, malignancy, and disseminated intravascular coagulation. These considerations highlight the need for further research to elucidate the mechanisms of the possible pleiotropic effects of the heparins, with a view to advancing treatments based upon heparin derivatives.

引用

页码：437 / 444

页数：8

共 91 条

[21] Heparin and its derivatives in the treatment of arterial thrombosis: a review [J].

Dvorak, M. ;

Vlasin, M. ;

Dvorakova, M. ;

Rauser, P. ;

Lexmaulova, L. ;

Gregor, Z. ;

Staffa, R. .

VETERINARNI MEDICINA, 2010, 55 (11) :523-546

[22] Mechanisms of Disease: Hypoxia and Inflammation. [J].

Eltzschig, Holger K. ;

Carmeliet, Peter .

NEW ENGLAND JOURNAL OF MEDICINE, 2011, 364 (07) :656-665

[23] Low molecular weight heparin downregulates tissue factor expression and activity by modulating growth factor receptor-mediated induction of nuclear factor-κB [J].

Ettelaie, Camille ;

Fountain, Donna ;

Collier, Mary Elizabeth W. ;

ElKeeb, Azza M. ;

Xiao, Yu Pei ;

Maraveyas, Anthony .

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 2011, 1812 (12) :1591-1600

[24] P-selectin promotes neutrophil extracellular trap formation in mice [J].

Etulain, Julia ;

Martinod, Kimberly ;

Wong, Siu Ling ;

Cifuni, Stephen M. ;

Schattner, Mirta ;

Wagner, Denisa D. .

BLOOD, 2015, 126 (02) :242-246

[25] Rationale and design of the Cardiovascular Inflammation Reduction Trial: A test of the inflammatory hypothesis of atherothrombosis [J].

Everett, Brendan M. ;

Pradhan, Aruna D. ;

Solomon, Daniel H. ;

Paynter, Nina ;

MacFadyen, Jean ;

Zaharris, Elaine ;

Gupta, Milan ;

Clearfield, Michael ;

Libby, Peter ;

Hasan, Ahmed A. K. ;

Glynn, Robert J. ;

Ridker, Paul M. .

AMERICAN HEART JOURNAL, 2013, 166 (02) :199-+

[26] The synthetic pentasaccharide fondaparinux reduces coagulation, inflammation and neutrophil accumulation in kidney ischemia-reperfusion injury [J].

Frank, RD ;

Schabbauer, G ;

Holscher, T ;

Sato, Y ;

Tencati, M ;

Pawlinski, R ;

Mackman, N .

JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2005, 3 (03) :531-540

[27] A non-anticoagulant synthetic pentasaccharide reduces inflammation in a murine model of kidney ischemia-reperfusion injury [J].

Frank, Rolf Dario ;

Holscher, Todd ;

Schabbauer, Gernot ;

Tencati, Michael ;

Pawlinski, Rafal ;

Weitz, Jeffrey I. ;

Mackman, Nigel .

THROMBOSIS AND HAEMOSTASIS, 2006, 96 (06) :802-806

[28] Extracellular DNA traps promote thrombosis [J].

Fuchs, Tobias A. ;

Brill, Alexander ;

Duerschmied, Daniel ;

Schatzberg, Daphne ;

Monestier, Marc ;

Myers, Daniel D., Jr. ;

Wrobleski, Shirley K. ;

Wakefield, Thomas W. ;

Hartwig, John H. ;

Wagner, Denisa D. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (36) :15880-15885

[29]

Gao YG, 2005, MOL CELLS, V19, P350

[30] Heparin Responses in Vascular Smooth Muscle Cells Involve cGMP-Dependent Protein Kinase (PKG) [J].

Gilotti, Albert C. ;

Nimlamool, Wutigri ;

Pugh, Raymond ;

Slee, Joshua B. ;

Barthol, Trista C. ;

Miller, Elizabeth A. ;

Lowe-Krentz, Linda J. .

JOURNAL OF CELLULAR PHYSIOLOGY, 2014, 229 (12) :2142-2152

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