More than an anticoagulant: Do heparins have direct anti-inflammatory effects?

被引：153

作者：

Poterucha, Timothy J. ^{[1
]}

Libby, Peter ^{[2
]}

Goldhaber, Samuel Z. ^{[2
]}

机构：

[1] Harvard Med Sch, Brigham & Womens Hosp, Dept Med, Boston, MA USA

[2] Harvard Med Sch, Brigham & Womens Hosp, Div Cardiovasc Med, Dept Med, Boston, MA USA

来源：

THROMBOSIS AND HAEMOSTASIS | 2017年 / 117卷 / 03期

基金：

美国国家卫生研究院;

关键词：

Heparin; coagulation; inflammation; LOW-MOLECULAR-WEIGHT; NEUTROPHIL EXTRACELLULAR TRAPS; SMOOTH-MUSCLE-CELLS; TISSUE FACTOR; P-SELECTIN; KAPPA-B; VENOUS THROMBOEMBOLISM; INFLAMMATORY DISEASES; ENDOTHELIAL-CELLS; CANCER-PATIENTS;

D O I：

10.1160/TH16-08-0620

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The heparins, well-known for their anticoagulant properties, may also have anti-inflammatory effects that could contribute to their effectiveness in the treatment of venous thromboembolism and other vascular diseases. This review focuses on the inflammatory pathophysiology that underlies the development of thrombosis and the putative effects of heparin on these pathways. We present evidence supporting the use of heparin for other indications, including autoimmune disease, malignancy, and disseminated intravascular coagulation. These considerations highlight the need for further research to elucidate the mechanisms of the possible pleiotropic effects of the heparins, with a view to advancing treatments based upon heparin derivatives.

引用

页码：437 / 444

页数：8

共 91 条

[11]

2-E

[12] Augmented Expression and Activity of Extracellular Matrix-Degrading Enzymes in Regions of Low Endothelial Shear Stress Colocalize With Coronary Atheromata With Thin Fibrous Caps in Pigs [J].

Chatzizisis, Yiannis S. ;

Baker, Aaron B. ;

Sukhova, Galina K. ;

Koskinas, Konstantinos C. ;

Papafaklis, Michail I. ;

Beigel, Roy ;

Jonas, Michael ;

Coskun, Ahmet U. ;

Stone, Benjamin V. ;

Maynard, Charles ;

Shi, Guo-Ping ;

Libby, Peter ;

Feldman, Charles L. ;

Edelman, Elazer R. ;

Stone, Peter H. .

CIRCULATION, 2011, 123 (06) :621-630

[13] Intertwining of thrombosis and inflammation in atherosclerosis [J].

Croce, Kevin ;

Libby, Peter .

CURRENT OPINION IN HEMATOLOGY, 2007, 14 (01) :55-61

[14]

Cui HF, 1999, WORLD J GASTROENTERO, V5, P448

[15] Prolyl hydroxylase-1 negatively regulates IκB kinase-β, giving insight into hypoxia-induced NFκB activity [J].

Cummins, Eoin P. ;

Berra, Edurne ;

Comerford, Katrina M. ;

Ginouves, Amandine ;

Fitzgerald, Kathleen T. ;

Seeballuck, Fergal ;

Godson, Catherine ;

Nielsen, Jens E. ;

Moynagh, Paul ;

Pouyssegur, Jacques ;

Taylor, Cormac T. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (48) :18154-18159

[16] NETosis: A New Factor in Tumor Progression and Cancer-Associated Thrombosis [J].

Demers, Melanie ;

Wagner, Denisa D. .

SEMINARS IN THROMBOSIS AND HEMOSTASIS, 2014, 40 (03) :277-283

[17] Cancers predispose neutrophils to release extracellular DNA traps that contribute to cancer-associated thrombosis [J].

Demers, Melanie ;

Krause, Daniela S. ;

Schatzberg, Daphne ;

Martinod, Kimberly ;

Voorhees, Jaymie R. ;

Fuchs, Tobias A. ;

Scadden, David T. ;

Wagner, Denisa D. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012, 109 (32) :13076-13081

[18] Treatment with unfractionated heparin attenuates coagulation and inflammation in endotoxemic mice [J].

Ding, Renyu ;

Zhao, Dongmei ;

Guo, Renxuan ;

Zhang, Zhidan ;

Ma, Xiaochun .

THROMBOSIS RESEARCH, 2011, 128 (06) :E160-E165

[19] PHYSIOLOGIC ACTIONS OF HEPARIN NOT RELATED TO BLOOD CLOTTING [J].

DOUGHERTY, TF ;

DOLOWITZ, DA .

AMERICAN JOURNAL OF CARDIOLOGY, 1964, 14 (01) :18-&

[20] Low-dose low-molecular-weight heparin is anti-inflammatory during venous thrombosis [J].

Downing, LJ ;

Strieter, RM ;

Kadell, AM ;

Wilke, CA ;

Greenfield, LJ ;

Wakefield, TW .

JOURNAL OF VASCULAR SURGERY, 1998, 28 (05) :848-854

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