Polyunsaturated lysophosphatidic acid as a potential asthma biomarker

被引：37
作者：
Ackerman, Steven J. [1 ,2 ]
Park, Gye Young [2 ]
Christman, John W. [3 ]
Nyenhuis, Sharmilee [2 ]
Berdyshev, Evgeny [4 ]
Natarajan, Viswanathan [2 ,5 ]
机构：
[1] Univ Illinois, Dept Biochem & Mol Genet, Chicago, IL 60607 USA
[2] Univ Illinois, Coll Med, Dept Med, M-C 787,840 S Wood St, Chicago, IL 60612 USA
[3] Ohio State Univ, Sch Med, Dept Med, Columbus, OH 43210 USA
[4] Natl Jewish Hlth, Dept Med, Denver, CO 80206 USA
[5] Univ Illinois, Coll Med, Dept Pharmacol, Chicago, IL 60612 USA
来源：
BIOMARKERS IN MEDICINE | 2016年 / 10卷 / 02期
关键词：
airway epithelium; allergic airway inflammation; asthma biomarkers; autotaxin; bronchoalveolar lavage fluid; eosinophils; exhaled breath condensate; LPA receptors; lysophosphatidic acid (LPA); macrophages; AIRWAY INFLAMMATION; LYSOPHOSPHOLIPASE-D; AUTOTAXIN; ACTIVATION; LPA; EXPRESSION; REGULATOR; SECRETION; MIGRATION; PATHWAYS;
D O I：
10.2217/bmm.15.93
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Lysophosphatidic acid (LPA), a lipid mediator in biological fluids and tissues, is generated mainly by autotaxin that hydrolyzes lysophosphatidylcholine to LPA and choline. Total LPA levels are increased in bronchoalveolar lavage fluid from asthmatic lung, and are strongly induced following subsegmental bronchoprovocation with allergen in subjects with allergic asthma. Polyunsaturated molecular species of LPA (C22:5 and C22:6) are selectively synthesized in the airways of asthma subjects following allergen challenge and in mouse models of allergic airway inflammation, having been identified and quantified by LC/MS/MS lipidomics. This review discusses current knowledge of LPA production in asthmatic lung and the potential utility of polyunsaturated LPA molecular species as novel biomarkers in bronchoalveolar lavage fluid and exhaled breath condensate of asthma subjects.
引用
收藏
页码：123 / 135
页数：13
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