Intracellular lipid binding proteins of the small intestine

被引：63

作者：

Agellon, LB ^{[1
]}

Toth, MJ

Thomson, ABR

机构：

[1] Univ Alberta, Heritage Med Res Ctr 328, Canadian Inst Hlth Res Grp Mol & Cell Biol Lipids, Edmonton, AB T6G 2S2, Canada

[2] Univ Alberta, Dept Biochem, Edmonton, AB T6G 2S2, Canada

[3] Univ Alberta, Dept Med, Edmonton, AB T6G 2S2, Canada

[4] Novartis Inst Biomed Res, Summit, NJ USA

来源：

MOLECULAR AND CELLULAR BIOCHEMISTRY | 2002年 / 239卷 / 1-2期

基金：

加拿大健康研究院;

关键词：

fatty acid binding protein; intestinal fat absorption; I-FABP; L-FABP; ILBP;

D O I：

10.1023/A:1020520521025

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The small intestine contains three distinct proteins belonging to the intracellular lipid binding protein family: the liver-type fatty acid binding protein (L-FABP), the intestinal fatty acid binding protein (I-FABP) and the ileal lipid binding protein (ilbp). The function of these proteins in the small intestine has remained enigmatic. Targeted gene disruption studies may shed insights into the physiological importance of these proteins. In the case of I-FABP, this approach has demonstrated that the complete elimination of this protein in murine intestine does not compromise dietary fat absorption in vivo but is associated with the development of insulin resistance.

引用

页码：79 / 82

页数：4

共 30 条

[1] Postprandial lipemic response is modified by the polymorphism at codon 54 of the fatty acid-binding protein 2 gene [J].

Ågren, JJ ;

Valve, R ;

Vidgren, H ;

Laakso, M ;

Uusitupa, M .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 1998, 18 (10) :1606-1610

[2] AN AMINO-ACID SUBSTITUTION IN THE HUMAN INTESTINAL FATTY-ACID-BINDING PROTEIN IS ASSOCIATED WITH INCREASED FATTY-ACID-BINDING, INCREASED FAT OXIDATION, AND INSULIN-RESISTANCE [J].

BAIER, LJ ;

SACCHETTINI, JC ;

KNOWLER, WC ;

EADS, J ;

PAOLISSO, G ;

TATARANNI, PA ;

MOCHIZUKI, H ;

BENNETT, PH ;

BOGARDUS, C ;

PROCHAZKA, M .

JOURNAL OF CLINICAL INVESTIGATION, 1995, 95 (03) :1281-1287

[3]

BASS NM, 1985, J BIOL CHEM, V260, P1432

[4] Excess portal venous long-chain fatty acids induce syndrome X via HPA axis and sympathetic activation [J].

Benthem, L ;

Keizer, K ;

Wiegman, CH ;

De Boer, SF ;

Strubbe, JH ;

Steffens, AB ;

Kuipers, F ;

Scheurink, AJW .

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2000, 279 (06) :E1286-E1293

[5] The A54T polymorphism at the intestinal fatty acid binding protein 2 is associated with insulin resistance in glucose tolerant Caucasians [J].

Chiu, Ken C. ;

Chuang, Lee-Ming ;

Yoon, Carol .

BMC GENETICS, 2001, 2 (1)

[6] MOLECULAR-CLONING, EXPRESSION, AND CHARACTERIZATION OF A HUMAN INTESTINAL 15-KDA PROTEIN [J].

FUJITA, M ;

FUJII, H ;

KANDA, T ;

SATO, E ;

HATAKEYAMA, K ;

ONO, T .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1995, 233 (02) :406-413

[7] MOLECULAR-CLONING, TISSUE DISTRIBUTION, AND EXPRESSION OF A 14-KDA BILE ACID-BINDING PROTEIN FROM RAT ILEAL CYTOSOL [J].

GONG, YZ ;

EVERETT, ET ;

SCHWARTZ, DA ;

NORRIS, JS ;

WILSON, FA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (11) :4741-4745

[8] Identification of a bile acid-responsive element in the human ileal bile acid-binding protein gene -: Involvement of the farnesoid X receptor/9-cis-retinoic acid receptor heterodimer [J].

Grober, J ;

Zaghini, I ;

Fujii, H ;

Jones, SA ;

Kliewer, SA ;

Willson, TM ;

Ono, T ;

Besnard, P .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (42) :29749-29754

[9] Variation of the fatty acid binding protein 2 gene is not associated with obesity and insulin resistance in Japanese subjects [J].

Hayakawa, T ;

Nagai, Y ;

Nohara, E ;

Yamashita, H ;

Takamura, T ;

Abe, T ;

Nomura, G ;

Kobayashi, K .

METABOLISM-CLINICAL AND EXPERIMENTAL, 1999, 48 (05) :655-657

[10]

LOWE JB, 1987, J BIOL CHEM, V262, P5931

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