TIL Therapy Entering the Mainstream

被引：12

作者：

Coukos, George ^{[1
,2
,3
]}

机构：

[1] Univ Lausanne, Ludwig Inst Canc Res, Lausanne, Switzerland

[2] Univ Lausanne, Dept Oncol, Lausanne, Switzerland

[3] Lausanne Univ Hosp, Lausanne, Switzerland

来源：

NEW ENGLAND JOURNAL OF MEDICINE | 2022年 / 387卷 / 23期

关键词：

TUMOR-INFILTRATING LYMPHOCYTES; INTERLEUKIN-2; IMMUNOTHERAPY; MELANOMA;

D O I：

10.1056/NEJMe2214655

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Melanomas have long been considered to be immunogenic tumors. Although anti-programmed death 1 (PD-1) therapy has been approved worldwide as first-line treatment, many patients do not benefit from it, so there is an important therapeutic gap. Adoptive cell therapy with tumor-infiltrating lymphocytes (TILs) was described in the 1980s by Rosenberg and colleagues.(1) This personalized treatment for cancer is based on the infusion of autologous T lymphocytes that have been obtained directly from surgically removed autologous tumors and then expanded in culture with the use of interleukin-2 stimulation. Both preconditioning lymphodepletion with high-dose, nonmyeloablative chemotherapy and the intravenous administration of high-dose . . .

引用

页码：2185 / 2186

页数：2

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