Antiplasmodial and other constituents from four Indonesian Garcinia spp.

被引：57

作者：

Elfita, Elfita ^{[2
]}

Muharni, Muharni ^{[2
]}

Latief, Madyawati ^{[3
]}

Darwati, Darwati ^{[4
]}

Widiyantoro, Ari ^{[5
]}

Supriyatna, Supriyatna ^{[6
]}

Bahti, Husein H. ^{[4
]}

Dachriyanus, Dachriyanus ^{[7
]}

Cos, Paul ^{[8
]}

Maes, Louis ^{[8
]}

Foubert, Kenne ^{[1
]}

Apers, Sandra ^{[1
]}

Pieters, Luc ^{[1
]}

机构：

[1] Univ Antwerp, Dept Pharmaceut Sci, Lab Pharmacognosy & Pharmaceut Anal, Antwerp, Belgium

[2] Sriwijaya Univ, Dept Chem, Fac Math & Nat Sci, Palembang, Indonesia

[3] Univ Jambi, Fac Agr, Jambi, Indonesia

[4] Padjadjaran State Univ, Dept Chem, Fac Math & Nat Sci, Bandung, Indonesia

[5] Tanjungpura Univ, Dept Chem, Fac Math & Nat Sci, Pontianak, Indonesia

[6] Padjadjaran State Univ, Fac Pharm, Bandung, Indonesia

[7] Andalas Univ, Fac Pharm, Padang, Indonesia

[8] Univ Antwerp, Fac Pharmaceut Biomed & Vet Sci, Lab Microbiol Parasitol & Hyg, Antwerp, Belgium

来源：

PHYTOCHEMISTRY | 2009年 / 70卷 / 07期

关键词：

Garcinia griffithii; Garcinia celebica; Garcinia cornea; Garcinia cymosa; Clusiaceae; 1,5-Dihydroxy-3,6-dimethoxy-2,7-diprenylxanthone; Isoxanthochymol; Garcihombronane D; 3 beta-Hydroxy-5-glutinen-28-oic acid; Antiprotozoal activity; Plasmodium falciparum; LEADING COMPOUNDS; NATURAL-PRODUCTS; ROOT BARK; XANTHONES; FRIEDOLANOSTANES; ASSIGNMENTS; LANOSTANES; BENZOPHENONES; TRITERPENOIDS; CHEMOTHERAPY;

D O I：

10.1016/j.phytochem.2009.04.024

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Phytochemical investigations of four Garcinia spp. from Indonesia, i.e. Garcinia griffithii T. Anderson, Garcinia celebica L, Garcinia cornea L and Garcinia cymosa K. chum (Clusiaceae), have resulted in the isolation of a xanthone, 1,5-dihydroxy-3,6-dimethoxy-2,7-diprenylxanthone, 1,7-dihydroxyxanthone, isoxanthochymol, beta-sitosterol-3-O-beta-D-glucoside and stigmasterol-3-O-beta-D-glucoside from the stem bark of G. griffithii; friedelin and 3 beta-hydroxy-23-oxo-9,16-lanostadien-26-oic acid or garcihombronane D from leaves of G. celebica; 23-hydroxy-3-oxo-cycloart-24-en-26-oic acid and epicatechin from stem bark of G. cornea; (+/-)-morelloflavone, morelloflavone-7-O-beta-D-glucoside or fukugiside, the triterpene 3 beta-hydroxy-5-glutinen-28-oic acid and canophyllol from stem bark of G. cymosa. The xanthone and garcihombronane D displayed a selective activity against Plasmodium falciparum; isoxanthochymol and the triterpene beta-hydroxy-5-glutinen-28-oic acid a broad but non-selective antiprotozoal activity. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：907 / 912

页数：6

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